Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006424
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2000-10-28
Brief Title:
Study of Brain Changes Shaped by Experience
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
fMRI and Spectroscopy Studies of Cortical Plasticity at 15 and 3 Tesla
Status:
COMPLETED
Status Verified Date:
2002-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI scans to explore how the brain changes reorganizes itself in response to learning and to brain lesions in healthy people and people with various physical disabilities
Normal volunteers and patients with disabilities including blindness limb amputation hemispherectomy removal of a cerebral hemisphere and stroke may be eligible for this study Candidates will be screened with medical and neurological examinations
Participants will have MRI scans while they lie still or perform certain movements as instructed MRI uses a strong magnetic field and radio waves instead of X-rays to show structural and chemical changes in tissues During the scan the subject lies on a table in a narrow cylinder containing a magnetic field He or she can speak with a staff member through an intercom system at all times during the procedure All participants will first have a scan to show brain structure which will take about 30 minutes A second scan will measure blood flow or biochemical concentration and will take from 1 to 2 12 hours
Depending on their disability patients will participate in one of the following tests
Blindness-This will study the ability of blind people to process tactile information
Stroke- This will study mechanisms underlying recovery of motor function after stroke The patient will perform voluntary movements or remain still during the scan
Amputation- This will study mechanisms underlying the ability of the brain to reorganize after amputation The patient will move different parts of the body or remain still during the scan
Hemispherectomy- This will study mechanisms underlying the ability of one side of the brain to control movements of both arms The patient will make different kinds of movements during the scan
Normal volunteers will participate in one of the following tests
Use-dependent plasticity- This will evaluate the effectiveness of amphetamine and placebo in demonstrating brain flexibility The volunteer will take an amphetamine or placebo inactive pill before the scan and then perform a specific exercise using the thumb
Motor fatigue- This will study the mechanisms that underlie fatigue which affect many patients with neurological conditions The volunteer will contract muscles in the forearm and hand for several minutes until he or she feels fatigue
Light deprivation- This will evaluate changes in the brain that occur after light deprivation The volunteer will remain at rest in the scanner for up to 150 minutes
Somatosensory stimulation-This will examine whether stimulation of the wrist can cause changes in hand representation in the part of the brain that controls movement The volunteer will make hand movements at different times during the test In addition mild electric shocks will be delivered to the wrist for up to 2 hours Although the shock intensity is regulated to avoid pain there may be some discomfort
Normal volunteers and patients with disabilities including blindness limb amputation hemispherectomy removal of a cerebral hemisphere and stroke may be eligible for this study Candidates will be screened with medical and neurological examinations
Participants will have MRI scans while they lie still or perform certain movements as instructed MRI uses a strong magnetic field and radio waves instead of X-rays to show structural and chemical changes in tissues During the scan the subject lies on a table in a narrow cylinder containing a magnetic field He or she can speak with a staff member through an intercom system at all times during the procedure All participants will first have a scan to show brain structure which will take about 30 minutes A second scan will measure blood flow or biochemical concentration and will take from 1 to 2 12 hours
Depending on their disability patients will participate in one of the following tests
Blindness-This will study the ability of blind people to process tactile information
Stroke- This will study mechanisms underlying recovery of motor function after stroke The patient will perform voluntary movements or remain still during the scan
Amputation- This will study mechanisms underlying the ability of the brain to reorganize after amputation The patient will move different parts of the body or remain still during the scan
Hemispherectomy- This will study mechanisms underlying the ability of one side of the brain to control movements of both arms The patient will make different kinds of movements during the scan
Normal volunteers will participate in one of the following tests
Use-dependent plasticity- This will evaluate the effectiveness of amphetamine and placebo in demonstrating brain flexibility The volunteer will take an amphetamine or placebo inactive pill before the scan and then perform a specific exercise using the thumb
Motor fatigue- This will study the mechanisms that underlie fatigue which affect many patients with neurological conditions The volunteer will contract muscles in the forearm and hand for several minutes until he or she feels fatigue
Light deprivation- This will evaluate changes in the brain that occur after light deprivation The volunteer will remain at rest in the scanner for up to 150 minutes
Somatosensory stimulation-This will examine whether stimulation of the wrist can cause changes in hand representation in the part of the brain that controls movement The volunteer will make hand movements at different times during the test In addition mild electric shocks will be delivered to the wrist for up to 2 hours Although the shock intensity is regulated to avoid pain there may be some discomfort
Detailed Description:
The purpose of this protocol is to investigate plastic changes in human cerebral cortex in health and disease The overall hypothesis is that it is possible to identify neuroimaging patterns reflecting reorganization in the human cerebral cortex using fMRI and that it is possible to obtain information on the mechanisms underlying some of these plastic changes by using magnetic resonance spectroscopy MRS of GABA This information is potentially important for the understanding of mechanisms of cortical reorganization operating in humans Patients and normal volunteers will be scanned at rest and during performance of different tasks These studies should provide new information on mechanisms of human plasticity The MRI techniques used for that purpose are functional MRI fMRI MR spectroscopy MRS and conventional MRI with magnets between 15 and 4 tesla
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-N-0012 | None | None | None |