Ignite Creation Date:
2024-05-06 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 12:51 PM
Study NCT ID:
NCT03621449
Status:
WITHDRAWN
Last Update Posted:
2022-01-11
First Post:
2018-05-17
Brief Title:
Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock
Sponsor:
Region Skane
Organization:
Region Skane
Study Overview
Official Title:
Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock
Status:
WITHDRAWN
Status Verified Date:
2022-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Lack of funding
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VIPS
Brief Summary:
The objective of the present study is to investigate accuracy of changes in cardiac output following passive leg raising as estimated by transthoracic ultrasound as method to predict fluid responsiveness and compare that to changes in cardiac output following PLR as estimated by calibrated pulse contour analysis as method to predict fluid responsiveness in patients with septic shock
Detailed Description:
One method to predict fluid responsiveness is to increase preload by transferring blood from the lower extremities to the central compartment through a passive leg raising PLR maneuver and then measure the resulting change in cardiac output It was recently suggested that an increase in cardiac output following PLR had a high accuracy compared other methods to test fluid responsiveness Different methods to estimate change in cardiac output have been used in studies investigating accuracy of PLR Most commonly calibrated pulse contour analysis has been used in mechanically ventilated patients whereas transthoracic echocardiography TTEhas been used in spontaneously breathing patients While TTE offers the advantage of being less invasive than calibrated pulse contour analysis it is technically challenging and user dependent and the accuracy of the two methods has not been compared
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None