Ignite Creation Date:
2024-05-05 @ 4:48 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00310323
Status:
COMPLETED
Last Update Posted:
2009-03-19
First Post:
2006-03-30
Brief Title:
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
Sponsor:
Virginia Commonwealth University
Organization:
Virginia Commonwealth University
Study Overview
Official Title:
Effect of Chronic Intermittent Nocturnal Hypoxia on Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
Status:
COMPLETED
Status Verified Date:
2009-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems liver that break down drugs in children with obstructive sleep apnea syndrome OSAS
Detailed Description:
The purpose of this study is to determine the effect of chronic intermittent nocturnal hypoxia on selected hepatic drug-metabolizing enzyme systems in children with OSAS The specific aims are to evaluate the activities of cytochrome P450 CYP1A2 N-acetyltransferase-2 NAT-2 xanthine oxidase XOand CYP2D6 in children with OSAS and to determine the effect of OSAS treatment on the activities of these enzyme systems
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None