Ignite Creation Date:
2024-05-05 @ 4:48 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00310427
Status:
COMPLETED
Last Update Posted:
2010-04-20
First Post:
2006-04-01
Brief Title:
Effect of LY686017 on Alcohol Craving
Sponsor:
National Institute on Alcohol Abuse and Alcoholism NIAAA
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
NK1 Receptor Antagonism for Treatment of Anxiety and Craving in Anxious Alcohol Dependent Subjects During Early Abstinence
Status:
COMPLETED
Status Verified Date:
2010-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine whether the experimental drug LY686017 can reduce a persons desire for alcohol A brain chemical called Substance P acts at places in the brain called NK1 receptors Substance P is released in response to stress and gives rise to behaviors that are thought to represent anxiety LY686017 blocks Substance P from acting at the NK1 receptors
People between 21 and 65 years of age who have been drinking on a regular basis for at least one month before entering the study who meet the criteria for alcohol dependence and who have an elevated score on a general test of anxiety may be eligible for this study
Participants are admitted to the NIH Clinical Center for 35 days They participate in an alcohol treatment program in addition to the research study After having been withdrawn from alcohol for at least 2 days participants receive either 50 mg of LY686017 or placebo an inactive substance that looks like the study drug every morning for 28 days In addition to drug treatment they undergo the following procedures
Functional magnetic resonance imaging fMRI In the last week of the study subjects undergo MRI to study the amount of blood going to brain structures thought to be involved in anxiety and craving During the procedure they look at pictures of faces exhibiting various emotions and pictures related to alcohol
Cue reactivity At the beginning and towards the end of the study subjects are asked to rate their alcohol craving and their anxiety level while they sniff and handle their favorite alcoholic beverage or water
Metyrapone test During weeks 1 and 4 of the study subjects are given metyrapone - a drug that interferes with the bodys ability to make the stress hormone cortisol - to determine how LY686017 affects the bodys hormonal response The drop in cortisol from metyrapone administration causes the brain to release ACTH a hormone that causes the adrenal gland to make cortisol
Trier test In the last week of the study subjects give a 5-minute speech to three people and are then asked to subtract numbers in their head Then they are asked to rate their feelings and desire for alcohol on two rating scales Blood is drawn from a saline lock at the beginning and end of the test to measure hormone levels
Rating scales Subjects complete an Obsessive Drinking Scale weekly and an Alcohol Urge Questionnaire and Comprehensive Psychiatric Rating Scale twice a week
Blood tests Blood samples are collected periodically to check blood chemistries clotting time and the amount of LY686017 in the blood
People between 21 and 65 years of age who have been drinking on a regular basis for at least one month before entering the study who meet the criteria for alcohol dependence and who have an elevated score on a general test of anxiety may be eligible for this study
Participants are admitted to the NIH Clinical Center for 35 days They participate in an alcohol treatment program in addition to the research study After having been withdrawn from alcohol for at least 2 days participants receive either 50 mg of LY686017 or placebo an inactive substance that looks like the study drug every morning for 28 days In addition to drug treatment they undergo the following procedures
Functional magnetic resonance imaging fMRI In the last week of the study subjects undergo MRI to study the amount of blood going to brain structures thought to be involved in anxiety and craving During the procedure they look at pictures of faces exhibiting various emotions and pictures related to alcohol
Cue reactivity At the beginning and towards the end of the study subjects are asked to rate their alcohol craving and their anxiety level while they sniff and handle their favorite alcoholic beverage or water
Metyrapone test During weeks 1 and 4 of the study subjects are given metyrapone - a drug that interferes with the bodys ability to make the stress hormone cortisol - to determine how LY686017 affects the bodys hormonal response The drop in cortisol from metyrapone administration causes the brain to release ACTH a hormone that causes the adrenal gland to make cortisol
Trier test In the last week of the study subjects give a 5-minute speech to three people and are then asked to subtract numbers in their head Then they are asked to rate their feelings and desire for alcohol on two rating scales Blood is drawn from a saline lock at the beginning and end of the test to measure hormone levels
Rating scales Subjects complete an Obsessive Drinking Scale weekly and an Alcohol Urge Questionnaire and Comprehensive Psychiatric Rating Scale twice a week
Blood tests Blood samples are collected periodically to check blood chemistries clotting time and the amount of LY686017 in the blood
Detailed Description:
Background
Alcoholism is a chronic relapsing disorder characterized by cycles of intoxication interspersed with phases of withdrawal and abstinence Co-morbidity with depression and anxiety disorders is high Even in absence of independent psychiatric co-morbidity anxiety symptoms are almost invariably present during early as well as protracted abstinence sensitized over repeated cycles of intoxication and withdrawal and are correlated with craving for alcohol upon exposure to alcohol associated cues This psychopathology is likely to maintain the dependent state since it has been shown that stress and negative affective states are major relapse triggering factors Substance P released in the amygdala in response to stress acts at NK1 receptors as an important mediator of behavioral stress effects in experimental animals Blockade of this receptor subtype represents a novel principle for anxiolytic like actions which is well documented in animal models and has some supportive data in humans Furthermore decreased opiate reward following NK1 receptor inaction is indicated by the reports that deletion of the NK1 receptor decreases both conditioned place preference and self-administration of opiates while a similar reduction of alcohol reward is suggested by preliminary data showing decreased voluntary intake of alcohol in NK1 null-mutants
Aims
The present study is aimed at providing an initial exploratory evaluation of whether the NK1 receptor is a candidate target for treatment of alcohol dependence that would merit further clinical development in conventional full-scale clinical trial designs To evaluate this the aim of the present study is to determine whether NK1 antagonism can beneficially affect in anxious alcohol dependent subjects during early abstinence surrogate variables correlated with clinical outcomes ie
reduce craving for alcohol measured as baseline self-reported urges or in response to presentation of alcohol associated cues
reduce negative affect
influence corresponding objective measures brain fMRI responses to alcohol-associated cues and to fear stimuli respectively and endocrine stress responses
This study will address this aim using a novel orally bioavailable and brain penetrant NK1 antagonist Positive data in this exploratory study would be the first of their kind and provide a rationale for evaluating the NK1 antagonist for anti-craving anti-dipsotropic and anti-anxiety actions in alcohol dependent subjects in a longer term suggesting that it might aid relapse prevention
Methods
The study will be carried out in 50 subjects aged 21-65 years with alcohol dependence as their primary complaint and without other serious medical or psychiatric conditions An additional inclusion criterion will be the presence or history of significant anxiety symptoms on self report Subjects will be admitted to the NIAAA research inpatient unit at the NIH Clinical Center through a platform training and natural history protocol which provides basic assessments and standard withdrawal treatment if needed Patients will enter into the present protocol once such treatment if needed is completed The present protocol will be started with a 1 week single blind placebo lead-in During this phase a baseline alcohol cue-reactivity session will be carried out according to established procedures and urges to drink will be assessed Cue-responsive subjects only appr 70 of alcohol dependent inpatients will be randomized to active treatment or placebo and enter the active treatment phase The active treatment arm will receive 50 mg once daily of LY686017by oral intake while the placebo group will continue to receive placebo in a double-blind fashion The duration of active treatment will be 3 weeks
Patients will remain hospitalized throughout this protocol During this period no psychotropic medication will be allowed and abstinence from alcohol and other drugs will be monitored Measures of craving will be obtained using 1 ratings completed twice a week on the established Alcohol Urge Questionnaire AUQ 2 assessments of urge to drink at baseline and under medication during an established cue reactivity paradigm during which each patient undergoes an invivo exposure to his or her preferred alcoholic beverage The medicated cue reactivity session will follow immediately after the Trier Test a social stress task that independently induces urges for alcohol stress induced craving and augments subsequent cue-induced urges stress-potentiated cue induced craving 3 weekly assessment of alcohol related cognitions using the Obsessive Drinking Scale ODS a pharmacologically validated subscale of the established Obsessive Compulsive Drinking Scale OCDS In addition measures of anxiety and depression symptoms will be obtained twice-weekly using the Comprehensive Psychiatric Rating Scale CPRS During the last treatment week subjects will undergo an fMRI scan using established paradigms to evoke emotional responses and to evoke alcohol-cue associated responses respectively Psychophysiological measures will be obtained in conjunction with the scan Blood draws will be carried out on the day of the scan to allow for analysis of plasma concentrations of the experimental drug The neuroendocrine stress response will be probed using the standard metyrapone challenge test in unmedicated state following the baseline CR session and then again under active treatment or placebo following the fMRI scan
Alcoholism is a chronic relapsing disorder characterized by cycles of intoxication interspersed with phases of withdrawal and abstinence Co-morbidity with depression and anxiety disorders is high Even in absence of independent psychiatric co-morbidity anxiety symptoms are almost invariably present during early as well as protracted abstinence sensitized over repeated cycles of intoxication and withdrawal and are correlated with craving for alcohol upon exposure to alcohol associated cues This psychopathology is likely to maintain the dependent state since it has been shown that stress and negative affective states are major relapse triggering factors Substance P released in the amygdala in response to stress acts at NK1 receptors as an important mediator of behavioral stress effects in experimental animals Blockade of this receptor subtype represents a novel principle for anxiolytic like actions which is well documented in animal models and has some supportive data in humans Furthermore decreased opiate reward following NK1 receptor inaction is indicated by the reports that deletion of the NK1 receptor decreases both conditioned place preference and self-administration of opiates while a similar reduction of alcohol reward is suggested by preliminary data showing decreased voluntary intake of alcohol in NK1 null-mutants
Aims
The present study is aimed at providing an initial exploratory evaluation of whether the NK1 receptor is a candidate target for treatment of alcohol dependence that would merit further clinical development in conventional full-scale clinical trial designs To evaluate this the aim of the present study is to determine whether NK1 antagonism can beneficially affect in anxious alcohol dependent subjects during early abstinence surrogate variables correlated with clinical outcomes ie
reduce craving for alcohol measured as baseline self-reported urges or in response to presentation of alcohol associated cues
reduce negative affect
influence corresponding objective measures brain fMRI responses to alcohol-associated cues and to fear stimuli respectively and endocrine stress responses
This study will address this aim using a novel orally bioavailable and brain penetrant NK1 antagonist Positive data in this exploratory study would be the first of their kind and provide a rationale for evaluating the NK1 antagonist for anti-craving anti-dipsotropic and anti-anxiety actions in alcohol dependent subjects in a longer term suggesting that it might aid relapse prevention
Methods
The study will be carried out in 50 subjects aged 21-65 years with alcohol dependence as their primary complaint and without other serious medical or psychiatric conditions An additional inclusion criterion will be the presence or history of significant anxiety symptoms on self report Subjects will be admitted to the NIAAA research inpatient unit at the NIH Clinical Center through a platform training and natural history protocol which provides basic assessments and standard withdrawal treatment if needed Patients will enter into the present protocol once such treatment if needed is completed The present protocol will be started with a 1 week single blind placebo lead-in During this phase a baseline alcohol cue-reactivity session will be carried out according to established procedures and urges to drink will be assessed Cue-responsive subjects only appr 70 of alcohol dependent inpatients will be randomized to active treatment or placebo and enter the active treatment phase The active treatment arm will receive 50 mg once daily of LY686017by oral intake while the placebo group will continue to receive placebo in a double-blind fashion The duration of active treatment will be 3 weeks
Patients will remain hospitalized throughout this protocol During this period no psychotropic medication will be allowed and abstinence from alcohol and other drugs will be monitored Measures of craving will be obtained using 1 ratings completed twice a week on the established Alcohol Urge Questionnaire AUQ 2 assessments of urge to drink at baseline and under medication during an established cue reactivity paradigm during which each patient undergoes an invivo exposure to his or her preferred alcoholic beverage The medicated cue reactivity session will follow immediately after the Trier Test a social stress task that independently induces urges for alcohol stress induced craving and augments subsequent cue-induced urges stress-potentiated cue induced craving 3 weekly assessment of alcohol related cognitions using the Obsessive Drinking Scale ODS a pharmacologically validated subscale of the established Obsessive Compulsive Drinking Scale OCDS In addition measures of anxiety and depression symptoms will be obtained twice-weekly using the Comprehensive Psychiatric Rating Scale CPRS During the last treatment week subjects will undergo an fMRI scan using established paradigms to evoke emotional responses and to evoke alcohol-cue associated responses respectively Psychophysiological measures will be obtained in conjunction with the scan Blood draws will be carried out on the day of the scan to allow for analysis of plasma concentrations of the experimental drug The neuroendocrine stress response will be probed using the standard metyrapone challenge test in unmedicated state following the baseline CR session and then again under active treatment or placebo following the fMRI scan
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 06-AA-0129 | None | None | None |