Ignite Creation Date:
2024-05-05 @ 11:07 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005249
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Epidemiology of Blood Pressure Insulin Salt Transport
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the roles of insulin lipids body weight and ion transport in blood pressure regulation
Detailed Description:
BACKGROUND
Insulin levels are consistently related to blood pressure obesity and blood lipids Insulin level correlation with sodium-lithium countertransport is limited to only one available study done in white normotensive predominantly normal weight women aged 45-52 The relationship between cellular sodium-hydrogen exchange activity and hypertension has been studied in rats and in a small study in humans Correlation of this transport with weight fasting insulin and lipid levels and sodium-lithium countertransport was not available in 1989
DESIGN NARRATIVE
The study was cross-sectional Subjects were stratified by weight plus or minus 10 percent of desirable weight 11 to 30 percent over desirable weight and 30 percent over desirable weight and by diastolic blood pressure 80 80-89 90-99 mmHg Blood pressure height weight waist and hip girth skinfold fasting and post-glucose load insulin glucose lipids creatinine maximal rates of red blood cell sodium-lithium countertransport and platelet sodium-hydrogen exchange pH and calcium concentrations were measured The strength and independence among these continuous variables were measured by Pearson correlations partial correlations and multiple regressions within each stratum and if appropriate over all strata The study examined the hypotheses that part of the relationship between obesity and blood pressure was due to insulin effects andor lipid effects on ion transport the relationship between ion transport and blood pressure was related to an abnormality of sodium-hydrogen exchange for which the observed increase in sodium-lithium countertransport was a marker increased blood pressure was related to the alteration of intracellular pH andor calcium concentration
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Insulin levels are consistently related to blood pressure obesity and blood lipids Insulin level correlation with sodium-lithium countertransport is limited to only one available study done in white normotensive predominantly normal weight women aged 45-52 The relationship between cellular sodium-hydrogen exchange activity and hypertension has been studied in rats and in a small study in humans Correlation of this transport with weight fasting insulin and lipid levels and sodium-lithium countertransport was not available in 1989
DESIGN NARRATIVE
The study was cross-sectional Subjects were stratified by weight plus or minus 10 percent of desirable weight 11 to 30 percent over desirable weight and 30 percent over desirable weight and by diastolic blood pressure 80 80-89 90-99 mmHg Blood pressure height weight waist and hip girth skinfold fasting and post-glucose load insulin glucose lipids creatinine maximal rates of red blood cell sodium-lithium countertransport and platelet sodium-hydrogen exchange pH and calcium concentrations were measured The strength and independence among these continuous variables were measured by Pearson correlations partial correlations and multiple regressions within each stratum and if appropriate over all strata The study examined the hypotheses that part of the relationship between obesity and blood pressure was due to insulin effects andor lipid effects on ion transport the relationship between ion transport and blood pressure was related to an abnormality of sodium-hydrogen exchange for which the observed increase in sodium-lithium countertransport was a marker increased blood pressure was related to the alteration of intracellular pH andor calcium concentration
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL039748 | NIH | None | httpsreporternihgovquickSearchR01HL039748 |