Ignite Creation Date:
2024-05-05 @ 9:36 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001391
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Bone Regeneration Using Bone Marrow Stromal Cells
Sponsor:
National Institute of Dental and Craniofacial Research NIDCR
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Bone Regeneration Using Bone Marrow Stromal Cells
Status:
COMPLETED
Status Verified Date:
2010-10-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Deficient or inappropriate healing of bone impacts clinical decision-making and treatment options in orthopedics oral and maxillofacial surgery plastic surgery and periodontics While a number of auto- and allografting techniques have been used to regenerate craniofacial defects caused by infective neoplastic or trauma-induced bone loss each method has significant limitations Our research group in the Craniofacial and Skeletal Diseases Branch of NIDCR has developed methods to culture and expand cell populations derived from mouse bone marrow stroma We believe that an important next step is to apply the information gained in animal studies to treat osseous defects in humans We propose to examine the potential of cultured human bone marrow stromal cells to serve as an abundant source of osteoblastic progenitor cells These cells will ultimately be used to graft craniofacial osseous defects In the course of this study we will 1 develop methods for the propagation and enrichment of osteoblastic progenitor cells from bone marrow stroma 2 test various vehicles for the transfer of bone marrow stromal cells to osseous defects in recipient animals 3 determine optimal culturing and transplantation conditions for the eventual transplantation of bone marrow stromal cells into human recipients These studies will define the parameters of bone marrow stromal cell transplantation and will generate models for future therapeutic strategies
Detailed Description:
Deficient or inappropriate healing of bone impacts clinical decision-making and treatment options in orthopedics oral and maxillofacial surgery plastic surgery and periodontics While a number of auto- and allografting techniques have been used to regenerate craniofacial defects caused by infective neoplastic or trauma-induced bone loss each method has significant limitations Our research group in the Craniofacial and Skeletal Diseases Branch of NIDCR has developed methods to culture and expand cell populations derived from mouse bone marrow stroma We believe that an important next step is to apply the information gained in animal studies to treat osseous defects in humans We propose to examine the potential of cultured human bone marrow stromal cells to serve as an abundant source of osteoblastic progenitor cells These cells will ultimately be used to graft craniofacial osseous defects In the course of this study we will 1 develop methods for the propagation and enrichment of osteoblastic progenitor cells from bone marrow stroma 2 test various vehicles for the transfer of bone marrow stromal cells to osseous defects in recipient animals 3 determine optimal culturing and transplantation conditions for the eventual transplantation of bone marrow stromal cells into human recipients These studies will define the parameters of bone marrow stromal cell transplantation and will generate models for future therapeutic strategies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 94-D-0188 | None | None | None |