Ignite Creation Date:
2024-05-06 @ 12:21 PM
Last Modification Date:
2024-10-26 @ 12:57 PM
Study NCT ID:
NCT03733015
Status:
COMPLETED
Last Update Posted:
2018-12-19
First Post:
2018-11-02
Brief Title:
Daily Sessions of rTMS to the Left DLPFC Modulate the Pain Thresholds and CPM
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Can Daily Sessions of rTMS to the Left DLPFC Boost Diffuse Noxious Inhibitory Control and Pain Thresholds in Healthy Subjects
Status:
COMPLETED
Status Verified Date:
2018-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The main purpose of the study is to assess whether repeated sessions of repetitive trancranial magnetic stimulation rTMS applied on left dorsolateral prefrontal cortex main boost the pain thresholds
Detailed Description:
Pain is the largest health-related burden on society and despite many decades of pain research there are still few effective treatments Since pain experience is a construct of the central nervous system CNS chronic pain has been recently thought to be a CNS disorder
Repetitive transcranial magnetic stimulation rTMS is a safe non-invasive technique for cerebral cortex stimulation and the clinical applications of which have expanded considerably in recent years Recent studies have been shown that classical rTMS to different cortical areas temporary reduce chronic and acute pain suggesting that rTMS may have some clinical application in future management of chronic pain However new rTMS paradigms involving theta burst stimulation TBS have recently been described with the major clinical advantage to be much shorter than classical rTMS The investigators hypothesize that cTBS would yield analgesic effects similar to or possibly even stronger than those produced by classical rTMS The investigators will carry out a sham-controlled randomized double-blind crossover study in healthy volunteers to compare the analgesic effects of two rTMS protocols over dorsolateral prefrontal cortex classical high-frequency rTMS 10 Hz and TBS As rTMS-induced analgesia may be dependent on changes in pain modulatory systems the investigators will analyze the effects of the stimulation on conditioned pain modulation CPM More specifically the investigators will compare the effects of multiple sessions of rTMS on the inhibition of a test experimental stimulus induced by heterotopic noxious stimuli to assess possible changes in diffuse noxious inhibitory controls
Repetitive transcranial magnetic stimulation rTMS is a safe non-invasive technique for cerebral cortex stimulation and the clinical applications of which have expanded considerably in recent years Recent studies have been shown that classical rTMS to different cortical areas temporary reduce chronic and acute pain suggesting that rTMS may have some clinical application in future management of chronic pain However new rTMS paradigms involving theta burst stimulation TBS have recently been described with the major clinical advantage to be much shorter than classical rTMS The investigators hypothesize that cTBS would yield analgesic effects similar to or possibly even stronger than those produced by classical rTMS The investigators will carry out a sham-controlled randomized double-blind crossover study in healthy volunteers to compare the analgesic effects of two rTMS protocols over dorsolateral prefrontal cortex classical high-frequency rTMS 10 Hz and TBS As rTMS-induced analgesia may be dependent on changes in pain modulatory systems the investigators will analyze the effects of the stimulation on conditioned pain modulation CPM More specifically the investigators will compare the effects of multiple sessions of rTMS on the inhibition of a test experimental stimulus induced by heterotopic noxious stimuli to assess possible changes in diffuse noxious inhibitory controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None