Ignite Creation Date:
2024-05-05 @ 4:50 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00327509
Status:
COMPLETED
Last Update Posted:
2009-08-20
First Post:
2006-05-17
Brief Title:
mRNA Expression in Lymphocytes of Glaucoma Patients
Sponsor:
University Hospital Basel Switzerland
Organization:
University Hospital Basel Switzerland
Study Overview
Official Title:
Messenger Ribonucleic Acid Expression in Lymphocytes of Glaucoma Patients
Status:
COMPLETED
Status Verified Date:
2009-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of the study is to compare messenger ribonucleic acid mRNA expression of various genes in lymphocytes between glaucoma patients and sex and age-matched healthy subjects A secondary objective is to analyze the impact of different forms of glaucoma or of a vasospastic propensity on the findings
Detailed Description:
Glaucoma is a leading cause of blindness world-wide Chronic primary open-angle glaucoma is the most common form among Caucasian patients The glaucoma patients will be divided into four groups 1 high tension glaucoma 2 normal tension glaucoma 3 pseudoexfoliation glaucoma and 4 juvenile glaucoma Healthy subjects are separated into two age groups Vasospastic propensity will be assessed with a questionnaire patients and subjects answering yes to the questions do you have always cold hands even during summer time and do other people tell you that you have cold hands will be classified as vasospastic and as normals if they deny a history of cold hands Blood will be drawn from an arm vein lymphocytes will be isolated and mRNA of following genes will be assessed in these lymphocytes
Nuclear proteins NF-kappa B XPGC P53 XIAP Multi-drug resistance proteins ABC 1 ABC 8 MDR 3 Adhesion protein ICAM 1 Blood brain barrier breakdown protein P2Y Energy metabolism proteins Adrenodoxin Adrenodoxin-reductase Cytochrome p450 Cytochrome-reductase Alcohol-dehydrogenase Tissue remodeling proteins MMP 9 MMP 8 MMP 14 TIMP 1 TIMP 2 TIMP 3 TIMP 4
Nuclear proteins NF-kappa B XPGC P53 XIAP Multi-drug resistance proteins ABC 1 ABC 8 MDR 3 Adhesion protein ICAM 1 Blood brain barrier breakdown protein P2Y Energy metabolism proteins Adrenodoxin Adrenodoxin-reductase Cytochrome p450 Cytochrome-reductase Alcohol-dehydrogenase Tissue remodeling proteins MMP 9 MMP 8 MMP 14 TIMP 1 TIMP 2 TIMP 3 TIMP 4
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None