Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005548
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Green Tea Consumption and Coronary Heart Disease
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine the prospective association of green tea consumption to the incidence and mortality of coronary heart disease CHD using multivariate analysis while controlling for the potential confounding effects of cholesterol triglycerides glucose and dietary nutrients
Detailed Description:
BACKGROUND
Both in vivo and in vitro experiments have show that flavonoids antioxidants which are rich in green tea are potentially as beneficial as vitamin E beta-carotene and vitamin C in reducing the risk of cardiovascular disease Thus the possible preventive effects of green tea on CHD have begun to raise research interests in green tea sufficiently to inquire about its beneficial effects formally in humans However few epidemiologic studies have been carried out to directly examine the effects of green tea on CHD The Honolulu Heart Program HHP is a 30 year longitudinal study of CHD and stroke among 8006 Japanese American men living on Oahu Hawaii Until the end of 1992 1888 men from this cohort were defined as having incident CHD this includes 396 deaths due to CHD The baseline examination for the HHP was conducted during 1965-68 A comprehensive physical examination and 24 hour dietary recall interview were administered Within the original cohort more than 75 percent men reported to have drunk green tea daily The amount consumed per day varied considerably from low to high doses The high prevalence of green tea consumption coupled with dose information ie low moderate and high consumption provides good opportunities to examine the relationships of green tea consumption and CHD
DESIGN NARRATIVE
The study uses the Honolulu Heart Program data to examine the prospective association of green tea consumption to the incidence and mortality of CHD using multivariate analysis while controlling for the potential confounding effects of cholesterol triglycerides glucose and dietary nutrients
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Both in vivo and in vitro experiments have show that flavonoids antioxidants which are rich in green tea are potentially as beneficial as vitamin E beta-carotene and vitamin C in reducing the risk of cardiovascular disease Thus the possible preventive effects of green tea on CHD have begun to raise research interests in green tea sufficiently to inquire about its beneficial effects formally in humans However few epidemiologic studies have been carried out to directly examine the effects of green tea on CHD The Honolulu Heart Program HHP is a 30 year longitudinal study of CHD and stroke among 8006 Japanese American men living on Oahu Hawaii Until the end of 1992 1888 men from this cohort were defined as having incident CHD this includes 396 deaths due to CHD The baseline examination for the HHP was conducted during 1965-68 A comprehensive physical examination and 24 hour dietary recall interview were administered Within the original cohort more than 75 percent men reported to have drunk green tea daily The amount consumed per day varied considerably from low to high doses The high prevalence of green tea consumption coupled with dose information ie low moderate and high consumption provides good opportunities to examine the relationships of green tea consumption and CHD
DESIGN NARRATIVE
The study uses the Honolulu Heart Program data to examine the prospective association of green tea consumption to the incidence and mortality of CHD using multivariate analysis while controlling for the potential confounding effects of cholesterol triglycerides glucose and dietary nutrients
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL062577 | NIH | None | httpsreporternihgovquickSearchR03HL062577 |