Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001788
Status:
TERMINATED
Last Update Posted:
2021-05-27
First Post:
1999-11-03
Brief Title:
Genetic Basis of Primary Immunodeficiencies
Sponsor:
National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Molecular Basis of Primary Immunodeficiencies
Status:
TERMINATED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Investigator left NIH
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to evaluate patients with primary immunodeficiency disorders to identify patients with mutations of the genes for the following proteins Jak3 STAT1 STAT4 interleukin-7 interleukin-7 receptor interleukin-12 receptor subunits and others
Patients will undergo screening history physical examination and clinical laboratory evaluation at referring institutions and tissue samples or cell lines will be sent to the NIH We will establish cell lines if necessary prepare DNA and RNA for molecular genetic analysis and study cytokine signal transduction in patient cell lines
Patients will undergo screening history physical examination and clinical laboratory evaluation at referring institutions and tissue samples or cell lines will be sent to the NIH We will establish cell lines if necessary prepare DNA and RNA for molecular genetic analysis and study cytokine signal transduction in patient cell lines
Detailed Description:
The purpose of this study is to evaluate patients with primary immunodeficiency disorders to identify patients with mutations of the genes for the following proteins Jak3 STAT1 STAT4 interleukin-7 interleukin-7 receptor interleukin-12 receptor subunits and others Patients will undergo screening history physical examination and clinical laboratory evaluation at referring institutions and tissue samples or cell lines will be sent to the NIH We will establish cell lines if necessary prepare DNA and RNA for molecular genetic analysis and study cytokine signal transduction in patient cell lines
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-AR-0004 | None | None | None |