Ignite Creation Date:
2024-05-05 @ 4:51 PM
Last Modification Date:
2024-10-26 @ 9:24 AM
Study NCT ID:
NCT00324181
Status:
UNKNOWN
Last Update Posted:
2009-08-04
First Post:
2006-05-08
Brief Title:
Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient
Sponsor:
Chinese University of Hong Kong
Organization:
Chinese University of Hong Kong
Study Overview
Official Title:
Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient
Status:
UNKNOWN
Status Verified Date:
2009-08
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
It is suggested the pathogenesis of normal-tension glaucoma NTG involves vascular dysregulation In the past studies it is well documented that many physical problems related to vascular dysregulation such as angina pectoris Friedman M et al 1974 Russek HI et al 1976 migraine Diener HC et al 1994 primary Raynauds disease Wagner HH et al 1993 and stroke Gainotti G et al 2001 Hayee Ma et al 2001 are associated with a high risk of depressive illness So NTG being a disease involving vascular dysregulation is postulated to be associated with psychopathology
Glaucoma increases after 40 year-old and the number of people over this age in Hong Kong is rapidly growing However we have no knowledge about the link between psychopathology and NTG in Hong Kong The present study is sought to overcome the limitation in previous research and the goals of present study are
To identify the prevalence of psychopathology of normal-tension glaucoma Hong Kong Chinese Out-patients attending a university-affiliated glaucoma clinic
To determine whether there are any differences among NTG patients patients with glaucoma other than NTG and control in terms of psychopathology and quality of life
Designs
Case-control study to compare among patients with normal-tension glaucoma NTG patients with glaucoma other than normal-tension glaucoma OTNTG and control in terms of psychopathology and quality of life
Glaucoma increases after 40 year-old and the number of people over this age in Hong Kong is rapidly growing However we have no knowledge about the link between psychopathology and NTG in Hong Kong The present study is sought to overcome the limitation in previous research and the goals of present study are
To identify the prevalence of psychopathology of normal-tension glaucoma Hong Kong Chinese Out-patients attending a university-affiliated glaucoma clinic
To determine whether there are any differences among NTG patients patients with glaucoma other than NTG and control in terms of psychopathology and quality of life
Designs
Case-control study to compare among patients with normal-tension glaucoma NTG patients with glaucoma other than normal-tension glaucoma OTNTG and control in terms of psychopathology and quality of life
Detailed Description:
Patients with chronic medical illness have been shown to have higher rates of depression and other psychopathology Kimmel PL et al 1998 Amato L et al 1996 Glaucoma is a chronic progressive ophthalmologic disease Treatment may involve the use of multiple medications and surgery Despite therapy many patients continue to worsen and some may even lose vision Because of this threat of potential loss of vision and the known depression-related side effects of some of topical glaucoma medication particular beta-blocker Cove-Smith JR et al 1985 it can be necessary hypothesized that glaucoma patient may have an increased prevalence of depression and other psychopathology It is also reasonable to apply similar hypothesis on the patients with normal-tension glaucoma
Normal-tension glaucoma NTG is a type of open-angle glaucoma defined as an optic neuropathy with visual-field defects together normal distribution of intraocular pressure 21 mmHg over a period of twenty-four hour as well as normal chamber-angle anatomy Levene RZ 1980 NTG is associated with different vasospastic syndrome including higher incidence of migraine Phelps CD et al 1985 angina pectoris Goldberg I et al 1981 silent myocardial ischemia Kaiser HJ et al 1993 and ocular vasopasm Flammer J et al 1991 Flammer J et al 1987 Orgul S et al 1995 Such associated clinical characteristics suggest that the pathogenesis of NTG involves vascular dysregulation In the past studies it is well documented that many physical problems related to vascular dysregulation such as angina pectoris Friedman M et al 1974 Russek HI et al 1976 migraine Diener HC et al 1994 primary Raynauds disease Wagner HH et al 1993 and stroke Gainotti G et al 2001 Hayee Ma et al 2001 are associated with a high risk of depressive illness So NTG being a disease involving vascular dysregulation is postulated to be associated with psychopathology
Normal-tension glaucoma NTG is a type of open-angle glaucoma defined as an optic neuropathy with visual-field defects together normal distribution of intraocular pressure 21 mmHg over a period of twenty-four hour as well as normal chamber-angle anatomy Levene RZ 1980 NTG is associated with different vasospastic syndrome including higher incidence of migraine Phelps CD et al 1985 angina pectoris Goldberg I et al 1981 silent myocardial ischemia Kaiser HJ et al 1993 and ocular vasopasm Flammer J et al 1991 Flammer J et al 1987 Orgul S et al 1995 Such associated clinical characteristics suggest that the pathogenesis of NTG involves vascular dysregulation In the past studies it is well documented that many physical problems related to vascular dysregulation such as angina pectoris Friedman M et al 1974 Russek HI et al 1976 migraine Diener HC et al 1994 primary Raynauds disease Wagner HH et al 1993 and stroke Gainotti G et al 2001 Hayee Ma et al 2001 are associated with a high risk of depressive illness So NTG being a disease involving vascular dysregulation is postulated to be associated with psychopathology
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None