Ignite Creation Date:
2025-12-24 @ 4:52 PM
Ignite Modification Date:
2025-12-28 @ 4:12 PM
Study NCT ID:
NCT02291250
Status:
UNKNOWN
Last Update Posted:
2021-02-21
First Post:
2014-11-11
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effect of Soft Fruit on Postprandial Blood Glucose
Sponsor:
University of Aberdeen
Organization:
Study Overview
Official Title:
Effect of Soft Fruit on Postprandial Blood Glucose
Status:
UNKNOWN
Status Verified Date:
2021-02
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dietary strategies for alleviating health complications associated with type 2 diabetes (T2D) are being pursued as alternatives to pharmaceutical interventions. Berries such as blackcurrants that are rich in polyphenols may influence carbohydrate digestion and absorption and thus postprandial glycaemia. In addition berries have been reported to alter incretins as well as to have anti-oxidant and anti-inflammatory properties that may also affect postprandial glycaemia. This study investigated the acute affect blackcurrants on glucose metabolism in overweight/obese volunteers .
Detailed Description:
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
There will be a one week minimum wash out period between each intervention. All interventions will be randomised and blinded as far as possible in a cross-over design where the volunteers are acting as their own control. The volunteers will be asked to consume a low phytochemical diet three days prior to taking the currants all occasions. In addition, they will be asked to record what they ate over the same period in a simple food diary.
The following intervention will be carried out on 16 overweight/obese male/postmenopausal female non-smoker volunteers:
1. Control: sugar matched (matched to currant sugar content) water with polycal (complex carbohydrate load)
2. Blackcurrants (which contain anthocyanins; 200grams) with polycal (complex carbohydrate load)
3. Blackcurrants (which contain anthocyanins; 200grams) with glucose (simple carbohydrate load)
4. Greencurrants (which naturally contain no anthocyanins; 200grams) with polycal (complex carbohydrate load)
Note: the polycal will contain the equivalent glucose load as given in intervention 3 assuming complete hydrolysis of all carbohydrates.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
There will be a one week minimum wash out period between each intervention. All interventions will be randomised and blinded as far as possible in a cross-over design where the volunteers are acting as their own control. The volunteers will be asked to consume a low phytochemical diet three days prior to taking the currants all occasions. In addition, they will be asked to record what they ate over the same period in a simple food diary.
The following intervention will be carried out on 16 overweight/obese male/postmenopausal female non-smoker volunteers:
1. Control: sugar matched (matched to currant sugar content) water with polycal (complex carbohydrate load)
2. Blackcurrants (which contain anthocyanins; 200grams) with polycal (complex carbohydrate load)
3. Blackcurrants (which contain anthocyanins; 200grams) with glucose (simple carbohydrate load)
4. Greencurrants (which naturally contain no anthocyanins; 200grams) with polycal (complex carbohydrate load)
Note: the polycal will contain the equivalent glucose load as given in intervention 3 assuming complete hydrolysis of all carbohydrates.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: