Ignite Creation Date:
2024-05-05 @ 4:53 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00333970
Status:
COMPLETED
Last Update Posted:
2014-10-09
First Post:
2006-06-02
Brief Title:
Predictors of Response to Cognitive Remediation in Schizophrenia
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Predictors of Response to Cognitive Remediation in Schizophrenia
Status:
COMPLETED
Status Verified Date:
2014-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine which variables predict improvement on a cognitive training task battery used for patients with schizophrenia and to determine the proportion of patients whose performance returns to normal following cognitive training
Detailed Description:
It has been suggested that level of cognitive function is a rate-limiter for the efficacy of other psychosocial treatments in schizophrenia Cognitive remediation which entails training and practice of successively more difficult cognitive exercises has shown efficacy in improving cognitive function However the rate of improvement has not been uniform among patients receiving this intervention Given the time- and cost-intensiveness of cognitive remediation it is important to examine variables that will predict response to this treatment as well as to examine the clinical significance of any improvement
The current proposal has two aims 1 to determine which neuropsychological demographic and illness variables predict response to cognitive remediation training and 2 to determine the proportion of patients whose performance returns to normal following cognitive remediation training For the first part of the proposed study 50 outpatients diagnosed with schizophrenia spectrum disorders will be invited to participate in an 8-week trial of cognitive remediation training Detailed neuropsychological demographic symptom and illness course variables will be collected prior to training at the conclusion of training and 4 months from study intake In order to answer the second question additional data on the computerized task performance for healthy controls will be collected and compared to patient data in order to determine what constitutes normal-range performance
The current proposal has two aims 1 to determine which neuropsychological demographic and illness variables predict response to cognitive remediation training and 2 to determine the proportion of patients whose performance returns to normal following cognitive remediation training For the first part of the proposed study 50 outpatients diagnosed with schizophrenia spectrum disorders will be invited to participate in an 8-week trial of cognitive remediation training Detailed neuropsychological demographic symptom and illness course variables will be collected prior to training at the conclusion of training and 4 months from study intake In order to answer the second question additional data on the computerized task performance for healthy controls will be collected and compared to patient data in order to determine what constitutes normal-range performance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| JMF0001 | OTHER | VACHS | None |