Ignite Creation Date:
2024-05-05 @ 4:54 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00341276
Status:
COMPLETED
Last Update Posted:
2024-07-15
First Post:
2006-06-19
Brief Title:
Esophageal Cancer Genetics Studies
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Esophageal Cancer Genetics Studies
Status:
COMPLETED
Status Verified Date:
2024-10-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this project is to understand the role of genetics in the etiology and prevention of upper gastrointestinal cancer primarily esophageal cancer but also cancers of the gastric cardia and body
Esophageal cancer is the second most common cause of cancer death in China and the seventh most common cause of cancer death worldwide Evidence suggests that genetic factors may play an important role in the etiology of this malignancy and identification of esophageal cancer susceptibility genes may allow screening of populations to identify persons at particularly high risk who could then be targeted for prevention strategies eg chemoprevention or early detection There are several lines of evidence supporting the idea that there is genetic susceptibility for esophageal cancer in high-risk Chinese populations including an association of positive family history with increased risk evidence of familial aggregation of cases and segregation analyses suggesting Mendelian inheritance in high-risk families
Several different but complementary approaches will be used to identify esophageal cancer susceptibility genes Because of etiologic similarities and for logistic reasons parallel efforts will be made with gastric cardia and body cancers First a tumornon-tumor study will be conducted in which a biological specimen bank consisting of samples tumor non-tumor venous blood finger stick blood and buccal cells from several hundred cases of esophageal gastric cardia and gastric body cancers will be developed in Taiyuan that can be used for the identification of esophageal as well as gastric cardia and body cancer susceptibility genes and potential early genetic markers of these cancers High-density genome-wide scans with microsatellite markers will be used in a limited number of cases to identify potential hot spots followed by further testing of these hot spots and other candidate markers in additional tumornon-tumor samples Premalignant morphologic lesions will also be examined Second blood samples for DNA will be collected from approximately 100 healthy individuals from high-risk Yangcheng County and low-risk Beijing areas to examine potential population differences in polymorphisms for selected genomic markers Third a large case-control study with cancers of the esophagus cardia and body of stomach will be conducted to evaluate polymorphisms in the candidate markers identified in other components of this project and to evaluate gene-environment interactions Finally a family study will be conducted to evaluate linkage of candidate markers with cancer in families having 2 or more cases with cancers of the esophagus cardia andor body of stomach
Esophageal cancer is the second most common cause of cancer death in China and the seventh most common cause of cancer death worldwide Evidence suggests that genetic factors may play an important role in the etiology of this malignancy and identification of esophageal cancer susceptibility genes may allow screening of populations to identify persons at particularly high risk who could then be targeted for prevention strategies eg chemoprevention or early detection There are several lines of evidence supporting the idea that there is genetic susceptibility for esophageal cancer in high-risk Chinese populations including an association of positive family history with increased risk evidence of familial aggregation of cases and segregation analyses suggesting Mendelian inheritance in high-risk families
Several different but complementary approaches will be used to identify esophageal cancer susceptibility genes Because of etiologic similarities and for logistic reasons parallel efforts will be made with gastric cardia and body cancers First a tumornon-tumor study will be conducted in which a biological specimen bank consisting of samples tumor non-tumor venous blood finger stick blood and buccal cells from several hundred cases of esophageal gastric cardia and gastric body cancers will be developed in Taiyuan that can be used for the identification of esophageal as well as gastric cardia and body cancer susceptibility genes and potential early genetic markers of these cancers High-density genome-wide scans with microsatellite markers will be used in a limited number of cases to identify potential hot spots followed by further testing of these hot spots and other candidate markers in additional tumornon-tumor samples Premalignant morphologic lesions will also be examined Second blood samples for DNA will be collected from approximately 100 healthy individuals from high-risk Yangcheng County and low-risk Beijing areas to examine potential population differences in polymorphisms for selected genomic markers Third a large case-control study with cancers of the esophagus cardia and body of stomach will be conducted to evaluate polymorphisms in the candidate markers identified in other components of this project and to evaluate gene-environment interactions Finally a family study will be conducted to evaluate linkage of candidate markers with cancer in families having 2 or more cases with cancers of the esophagus cardia andor body of stomach
Detailed Description:
The overall goal of this project is to understand the role of genetics in the etiology and prevention of upper gastrointestinal cancer primarily esophageal cancer but also cancers of the gastric cardia and body
Esophageal cancer is the fourth most common cause of cancer death in China and the seventh most common cause of cancer death worldwide Evidence suggests that genetic factors may play an important role in the etiology of this malignancy and identification of esophageal cancer susceptibility genes may allow screening of populations to identify persons at particularly high risk who could then be targeted for prevention strategies eg chemoprevention or early detection There are several lines of evidence supporting the idea that there is genetic susceptibility for esophageal cancer in high-risk Chinese populations including an association of positive family history with increased risk evidence of familial aggregation of cases and segregation analyses suggesting Mendelian inheritance in high-risk families
Several different but complementary approaches are proposed to identify esophageal cancer susceptibility genes Because of etiologic similarities and for logistic reasons parallel efforts will be made with gastric cardia and body cancers First a tumornontumor study will be conducted in which a biological specimen bank consisting of samples tumor nontumor venous blood finger stick blood and buccal cells from a total of approximately 150 cases each of esophageal gastric cardia and gastric body cancers will be developed in Taiyuan that can be used for the identification of esophageal as well as gastric cardia and body cancer susceptibility genes and potential early genetic markers of these cancers Comparative genomic hybridization and microsatellite markers will be used to scan the genome in up to 20 cases to identify potential hot spots followed by further testing of these hot spots and other candidate markers in additional tumornontumor samples Second blood samples for DNA will be collected from approximately 100 healthy individuals from high-risk Yangcheng County and low-risk Beijing areas to examine potential differences in polymorphisms for selected genomic markers Third a casecontrol study will be conducted to evaluate hot spots and candidate markers identified from the tumornontumor study and potential gene-environment interactions Finally a linkage study will be conducted by identifying and collecting information and DNA from cases and first degree relatives in special highly informative families those with 2 or more cases having obtainable DNA as well as population-based ascertainment and collection of information and DNA from all new cases from Yangcheng County
Esophageal cancer is the fourth most common cause of cancer death in China and the seventh most common cause of cancer death worldwide Evidence suggests that genetic factors may play an important role in the etiology of this malignancy and identification of esophageal cancer susceptibility genes may allow screening of populations to identify persons at particularly high risk who could then be targeted for prevention strategies eg chemoprevention or early detection There are several lines of evidence supporting the idea that there is genetic susceptibility for esophageal cancer in high-risk Chinese populations including an association of positive family history with increased risk evidence of familial aggregation of cases and segregation analyses suggesting Mendelian inheritance in high-risk families
Several different but complementary approaches are proposed to identify esophageal cancer susceptibility genes Because of etiologic similarities and for logistic reasons parallel efforts will be made with gastric cardia and body cancers First a tumornontumor study will be conducted in which a biological specimen bank consisting of samples tumor nontumor venous blood finger stick blood and buccal cells from a total of approximately 150 cases each of esophageal gastric cardia and gastric body cancers will be developed in Taiyuan that can be used for the identification of esophageal as well as gastric cardia and body cancer susceptibility genes and potential early genetic markers of these cancers Comparative genomic hybridization and microsatellite markers will be used to scan the genome in up to 20 cases to identify potential hot spots followed by further testing of these hot spots and other candidate markers in additional tumornontumor samples Second blood samples for DNA will be collected from approximately 100 healthy individuals from high-risk Yangcheng County and low-risk Beijing areas to examine potential differences in polymorphisms for selected genomic markers Third a casecontrol study will be conducted to evaluate hot spots and candidate markers identified from the tumornontumor study and potential gene-environment interactions Finally a linkage study will be conducted by identifying and collecting information and DNA from cases and first degree relatives in special highly informative families those with 2 or more cases having obtainable DNA as well as population-based ascertainment and collection of information and DNA from all new cases from Yangcheng County
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| OH95-C-N027 | None | None | None |