Ignite Creation Date:
2024-05-06 @ 12:58 PM
Last Modification Date:
2024-10-26 @ 1:06 PM
Study NCT ID:
NCT03894384
Status:
UNKNOWN
Last Update Posted:
2020-01-09
First Post:
2019-03-27
Brief Title:
The Value of TFF3 in Diagnosis of Gastric Cancer
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
The Value of Serum Trefoil Factor Family 3 TFF3 in Diagnosis of Gastric Cancer
Status:
UNKNOWN
Status Verified Date:
2019-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Gastric cancer GC is a cancer developing from the inner lining of the stomach The most common cause is infection by the bacterium Helicobacter pyloriwhich accounts for 60 of cases
Human pepsinogens HP are proenzymes for pepsin digestive enzymes produced by gastric chief cells classified into two groups pepsinogen I PGI and pepsinogen II PGII humen pepsinogens considered promising serological biomarkers for the screening of atrophic gastritis and gastric cancer
The trefoil factor family TFF of peptides comprises small 12-22kDa molecules that are secreted by the mammalian gastro-intestinal tractTrefoil factor family 3 TFF3 is a more stable non invasive biomarker of gastric cancer risk even in early gastric cancer
Human pepsinogens HP are proenzymes for pepsin digestive enzymes produced by gastric chief cells classified into two groups pepsinogen I PGI and pepsinogen II PGII humen pepsinogens considered promising serological biomarkers for the screening of atrophic gastritis and gastric cancer
The trefoil factor family TFF of peptides comprises small 12-22kDa molecules that are secreted by the mammalian gastro-intestinal tractTrefoil factor family 3 TFF3 is a more stable non invasive biomarker of gastric cancer risk even in early gastric cancer
Detailed Description:
Gastric cancer GC is a cancer developing from the inner lining of the stomachApproximately half of the gastric cancer cases are diagnosed during advanced stages One of the reasons for this is the invasiveness of esophagogastroduodenoscopy EGD screening examinations that leads to patients avoiding necessary tests
The most common cause is infection by the bacterium Helicobacter pylori Hpyloriwhich accounts for 60 of cases
The development of tools for the early diagnosis of gastric cancer and precancerous lesions of gastric cancer is important for reducing mortality increasing survival rates and improving quality of life
Endoscopy and biopsy are the reference standards for diagnosis and screening of gastric cancer but their use is limited for population-wide screening due to their invasivenessSubsequently it is necessary to identify novel simple cost-effective and manipulable screening methods for gastric cancer
Human pepsinogens HP are proenzymes for pepsin a digestive enzymes produced by gastric chief cellsbiochemically and immunochemically classified into two groups pepsinogen I PGI and pepsinogen II PGII humen pepsinogens considered promising serological biomarkers for the screening of atrophic gastritis and gastric cancerserum pepsinogen test provides a valuable method for detecting gastric cancer and atrophic gastritis
The limitation of the pepsinogen test as a non invasive serologic biomarker screening method is that the optimal cut-off value could be affected by several factors age gender and the test method itself
The trefoil factor family TFF of peptides comprises small 12-22kDa molecules that are secreted by the mammalian gastro-intestinal tract TFFs constitute a family of three peptides TFF1 TFF2 and TFF3 that are widely expressed in a tissue-specific manner in the gastro- intestinal tract Trefoil factor family 3 TFF3 is expressed in the goblet cells of the small and large intestines as well as the intestinal metaplasia in the stomach
The trefoil factor family TFF plays a key role in the maintenance of mucosal integrity and plays an impotant role in oncogenic transformation growth and metastatic extension of common human solid tumors including gastric cancer
SerumTFF3 showed good diagnostic power in both of H pylori positive and H pylori-negative gastric cancer and its serum levels were significantly higher in patients with advanced gastric cancer than that in patients with early gastric cancer
H pylori organisms live in gastric mucosa and attach to epithelial cells of stomach Because trefoil factor family 3 is not expressed in epithelial cells of the stomach and is only expressed in the intestinal goblet cells of the metaplasia of gastric cancer serum trefoil factor family 3 levels are less influenced by H pylori infection eradication aging and sex therefore serum trefoil factor family 3 is a more stable non invasive biomarker of gastric cancer risk even in early gastric cancer
The most common cause is infection by the bacterium Helicobacter pylori Hpyloriwhich accounts for 60 of cases
The development of tools for the early diagnosis of gastric cancer and precancerous lesions of gastric cancer is important for reducing mortality increasing survival rates and improving quality of life
Endoscopy and biopsy are the reference standards for diagnosis and screening of gastric cancer but their use is limited for population-wide screening due to their invasivenessSubsequently it is necessary to identify novel simple cost-effective and manipulable screening methods for gastric cancer
Human pepsinogens HP are proenzymes for pepsin a digestive enzymes produced by gastric chief cellsbiochemically and immunochemically classified into two groups pepsinogen I PGI and pepsinogen II PGII humen pepsinogens considered promising serological biomarkers for the screening of atrophic gastritis and gastric cancerserum pepsinogen test provides a valuable method for detecting gastric cancer and atrophic gastritis
The limitation of the pepsinogen test as a non invasive serologic biomarker screening method is that the optimal cut-off value could be affected by several factors age gender and the test method itself
The trefoil factor family TFF of peptides comprises small 12-22kDa molecules that are secreted by the mammalian gastro-intestinal tract TFFs constitute a family of three peptides TFF1 TFF2 and TFF3 that are widely expressed in a tissue-specific manner in the gastro- intestinal tract Trefoil factor family 3 TFF3 is expressed in the goblet cells of the small and large intestines as well as the intestinal metaplasia in the stomach
The trefoil factor family TFF plays a key role in the maintenance of mucosal integrity and plays an impotant role in oncogenic transformation growth and metastatic extension of common human solid tumors including gastric cancer
SerumTFF3 showed good diagnostic power in both of H pylori positive and H pylori-negative gastric cancer and its serum levels were significantly higher in patients with advanced gastric cancer than that in patients with early gastric cancer
H pylori organisms live in gastric mucosa and attach to epithelial cells of stomach Because trefoil factor family 3 is not expressed in epithelial cells of the stomach and is only expressed in the intestinal goblet cells of the metaplasia of gastric cancer serum trefoil factor family 3 levels are less influenced by H pylori infection eradication aging and sex therefore serum trefoil factor family 3 is a more stable non invasive biomarker of gastric cancer risk even in early gastric cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None