Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00342927
Status:
RECRUITING
Last Update Posted:
2024-07-15
First Post:
2006-06-19
Brief Title:
Family Investigation of Nephropathy and Diabetes FIND
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Family Investigation of Nephropathy and Diabetes FIND
Status:
RECRUITING
Status Verified Date:
2024-07-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Family Investigation of Nephropathy and Diabetes FIND is a multicenter study designed to identify genetic determinants of diabetic kidney disease FIND will be conducted in eleven centers and in many ethnic groups throughout the United States Two different strategies will be used to localize genes predisposing to kidney disease a family-based genetic linkage study and a case-control study that utilizes admixture linkage disequilibrium The center based at the Phoenix office of the National Institute of Diabetes and Digestive and Kidney Diseases NIDDK-Phoenix will conduct family-based linkage studies among American Indian populations in the southwestern United States
Participants index cases with diabetes and kidney disease will initially be recruited and their parents and siblings will also be invited to participate Genetic material from these participants will be used to genotype markers throughout the genome Linkage analysis will be conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease Linkage analyses will also be used to identify genes influencing traits related to diabetic kidney disease such as serum creatinine urinary protein excretion plasma glucose levels blood pressure and blood lipid levels Regions that show evidence for linkage will then be examined in more detail with both genetic linkage and association studies to attempt to identify the specific genes that influence diabetic kidney disease or related traits
The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops In the long run this may lead to improved treatment and prevention of diabetic kidney disease
Participants index cases with diabetes and kidney disease will initially be recruited and their parents and siblings will also be invited to participate Genetic material from these participants will be used to genotype markers throughout the genome Linkage analysis will be conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease Linkage analyses will also be used to identify genes influencing traits related to diabetic kidney disease such as serum creatinine urinary protein excretion plasma glucose levels blood pressure and blood lipid levels Regions that show evidence for linkage will then be examined in more detail with both genetic linkage and association studies to attempt to identify the specific genes that influence diabetic kidney disease or related traits
The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops In the long run this may lead to improved treatment and prevention of diabetic kidney disease
Detailed Description:
The Family Investigation of Nephropathy and Diabetes FIND is a multicenter study designed to identify genetic determinants of diabetic kidney disease FIND is conducted in eleven centers and in many ethnic groups throughout the United States Two different strategies are used to localize genes predisposing to kidney disease a family-based genetic linkageassociation study and a case-control study that uses admixture linkage disequilibrium The center based at the Phoenix office of the National Institute of Diabetes and Digestive and Kidney Diseases NIDDK-Phoenix conducts family-based linkageassociation studies among American Indian populations in the southwestern United States and in the indigenous Micronesian populations of the Territory of Guam and the Commonwealth of the Northern Mariana Islands CNMI
Participants index cases with diabetes and kidney disease are recruited and their parents and siblings are also invited to participate Members of target populations who are not related to index cases are also included and offered screening for diabetes and kidney disease this will facilitate association studies Genetic material from these participants is used to genotype markers throughout the genome Linkage and association analyses are conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease Linkage and association analyses are also used to identify genes influencing traits related to diabetic kidney disease such as serum creatinine urinary protein excretion plasma glucose levels blood pressure and blood lipid levels Genome-wide and candidate gene association studies are also conducted Regions that show evidence for linkage or association are then examined in more detail with both genetic linkage and association studies to attempt to identify the specific genes that influence diabetic kidney disease or related traits
The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops In the long run this may lead to improved treatment and prevention of diabetic kidney disease
Participants index cases with diabetes and kidney disease are recruited and their parents and siblings are also invited to participate Members of target populations who are not related to index cases are also included and offered screening for diabetes and kidney disease this will facilitate association studies Genetic material from these participants is used to genotype markers throughout the genome Linkage and association analyses are conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease Linkage and association analyses are also used to identify genes influencing traits related to diabetic kidney disease such as serum creatinine urinary protein excretion plasma glucose levels blood pressure and blood lipid levels Genome-wide and candidate gene association studies are also conducted Regions that show evidence for linkage or association are then examined in more detail with both genetic linkage and association studies to attempt to identify the specific genes that influence diabetic kidney disease or related traits
The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops In the long run this may lead to improved treatment and prevention of diabetic kidney disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-DK-N117 | None | None | None |