Ignite Creation Date:
2024-05-06 @ 1:09 PM
Last Modification Date:
2024-10-26 @ 1:09 PM
Study NCT ID:
NCT03943407
Status:
WITHDRAWN
Last Update Posted:
2021-01-15
First Post:
2019-05-07
Brief Title:
Characterization of the Toll-like Receptor 7-agonist Imiquimod 375 as a New Surrogate Model of Itch
Sponsor:
Aalborg University
Organization:
Aalborg University
Study Overview
Official Title:
Characterization of the Toll-like Receptor 7-agonist Imiquimod 375 as a New Surrogate Model of Itch
Status:
WITHDRAWN
Status Verified Date:
2021-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
The Imiquimod 375 was ineffective
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this research project is to design a new model of human itch by application of Zyclara cream Further the aim is to characterize the model and to verify if the mechanism of action of imiquimod follows the histaminergic or non-histaminergic pathway by using the anti-histamine drug doxepin The last goal is to evaluate the interaction between the activation of TLR7 receptor and the activation of TRPA1 and TRPM8 receptors which are two of the most important receptors involved in the transduction of noxious stimuli and to evaluate to which extent these three channel populations functionally overlap
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None