Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:25 AM
Study NCT ID:
NCT00340223
Status:
WITHDRAWN
Last Update Posted:
2012-05-10
First Post:
2006-06-19
Brief Title:
HLA-B35 Alleles and AIDS
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Comparison of HIV-1 Epitopes That May be Recognized by HLA-B3501 PY and -B3503 Px Early After Seroconversion and After Development of AIDS
Status:
WITHDRAWN
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will identify variations in the genome of the human immunodeficiency virus HIV early after infection and following the development of AIDS It will analyze genetic material and clinical data from HIV-positive individuals to assess differences in viral epitopes between patients with two different gene alleles alternative forms of a gene-B3501 and B3503 An epitope is a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response
HIV disease in people with the B3503 allele progresses significantly faster than it does in people with the B3501 allele This study might provide information that is potentially useful in developing a successful HIV vaccine
Blood samples and clinical data for analysis will be obtained from the Johns Hopkins Bloomberg School of Public Health the University of Pittsburgh the John H Stroger Jr Hospital of Cook County the Howard Brown Health Center Northwestern University and the University of California at Los Angeles
HIV disease in people with the B3503 allele progresses significantly faster than it does in people with the B3501 allele This study might provide information that is potentially useful in developing a successful HIV vaccine
Blood samples and clinical data for analysis will be obtained from the Johns Hopkins Bloomberg School of Public Health the University of Pittsburgh the John H Stroger Jr Hospital of Cook County the Howard Brown Health Center Northwestern University and the University of California at Los Angeles
Detailed Description:
The purpose of this study is to identify variations in the genome of HIV early after infection and following the development of AIDS to determine the location of escape mutations that might provide information about potential B35 epitopes These data will be useful in explaining the difference in disease progression between individuals possessing B35 Px alleles and those with B35 PY alleles We have previously shown that individuals with B35 Px alleles progress at a significantly faster rate compared to those with B35 PY alleles This study might provide information which is potentially useful in the development of a successful HIV vaccine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-C-N237 | None | None | None |