Ignite Creation Date:
2024-05-05 @ 4:56 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00358579
Status:
COMPLETED
Last Update Posted:
2017-03-17
First Post:
2006-07-30
Brief Title:
Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
Sponsor:
Singapore General Hospital
Organization:
Singapore General Hospital
Study Overview
Official Title:
A Randomised Double-blinded Multi-centre Trial Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest at the Emergency Department Preadmission Intravenous Vasopressin Adrenaline Outcome Trial PIVOT vII
Status:
COMPLETED
Status Verified Date:
2017-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PIVOT
Brief Summary:
The effectiveness of medications in cardiac arrest has been greatly debated and questioned Historically intravenous adrenaline has been the drug of choice since 1906 There have been few formal evaluations to determine the value of adrenaline for cardiac arrest and clinical trials have not been able to show any benefit with intravenous adrenaline compared to placebo or no treatment in the field
Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline
Thus the purpose of this study is to compare vasopressin and adrenaline in the treatment of cardiac arrest to answer the question whether there is an improvement in survival between vasopressin and adrenaline
Detailed Description:
The effectiveness of medications in cardiac arrest has been greatly debated and questioned Historically intravenous adrenaline has been the recommended drug of choice since 1906 There have been few formal evaluations to determine the value of adrenaline for cardiac arrest and clinical trials have not been able to show any benefit with intravenous adrenaline compared to placebo or no treatment in the field
More recently vasopressin has been used in patients with cardiac arrest In human studies on vasopressin clinical trials have produced conflicting results
The current study compared vasopressin and adrenaline in the treatment of cardiac arrest in patients presenting to the Emergency Department ED Specific outcomes included return of spontaneous circulation ROSC as measured by the presence of a palpable pulse at any time during resuscitation survival to hospital admission survival to discharge from hospital and functional status at discharge and at one year as measured by the Glasgow-Pittsburgh outcome categories
More recently vasopressin has been used in patients with cardiac arrest In human studies on vasopressin clinical trials have produced conflicting results
The current study compared vasopressin and adrenaline in the treatment of cardiac arrest in patients presenting to the Emergency Department ED Specific outcomes included return of spontaneous circulation ROSC as measured by the presence of a palpable pulse at any time during resuscitation survival to hospital admission survival to discharge from hospital and functional status at discharge and at one year as measured by the Glasgow-Pittsburgh outcome categories
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None