Ignite Creation Date:
2024-05-05 @ 4:57 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00354029
Status:
COMPLETED
Last Update Posted:
2011-07-20
First Post:
2006-07-18
Brief Title:
Effect of Perioperative iv Low-dose S Ketamine
Sponsor:
Asker Baerum Hospital
Organization:
Asker Baerum Hospital
Study Overview
Official Title:
Effect of Perioperative iv Low-dose S Ketamine in Patients Undergoing Hemorrhoidectomy
Status:
COMPLETED
Status Verified Date:
2011-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether the use of perioperative intravenous S ketamine reduces the amount and degree of postoperative pain
Furthermore the purpose of this study is to determine whether the use of perioperative intravenous S ketamine effects cognitive function in the early postoperative period
Furthermore the purpose of this study is to determine whether the use of perioperative intravenous S ketamine effects cognitive function in the early postoperative period
Detailed Description:
The mechanism of development of postoperative pain is complex Central and peripheral sensitization are playing an important role and this can lead to postoperative hypersensitization Several studies have shown that S ketamine can be effective to reduce sensitization and postoperative pain Ketamine 2-O-chlorophenyl-2-methylamino cyclohexanone is a N-Methyl-D-Aspartat NMDA receptor antagonist S ketamine has a four times stronger affinity to the NMDA receptor compared to R - ketamine The duration of action for S ketamine is shorter than R - ketamine and it has fewer side-effects
The purpose of this study is to compare the analgetic effect of pregabalin and placebo used in the perioperative period
The hypothesis is that perioperative intravenous S ketamine gives significant better analgesia than placebo without effecting cognitive function
The study is including patients undergoing hemorrhoidectomy
The purpose of this study is to compare the analgetic effect of pregabalin and placebo used in the perioperative period
The hypothesis is that perioperative intravenous S ketamine gives significant better analgesia than placebo without effecting cognitive function
The study is including patients undergoing hemorrhoidectomy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None