Ignite Creation Date:
2024-05-05 @ 11:08 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001161
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Abnormalities of the Eyes Anterior Chamber Iris Cornea and Lens
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Anomalies of the Anterior Chamber Angle Iris Cornea and Lens With or Without Glaucoma or Ocular Hypertension
Status:
COMPLETED
Status Verified Date:
2002-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate congenital or developmental eye abnormalities that affect the iris cornea and lens and are usually accompanied by elevated pressure within the eye These disorders can cause vision loss and the increased eye pressure can lead to glaucoma a condition that may also cause loss of eyesight
Patients with eye anterior chamber eye disease such as Axenfelds syndrome Riegers anomaly Peters anomaly iridocorneal endothelial syndrome megalocornea ocular hypertension and others are eligible for this study Participants will have a medical examination family history and comprehensive eye examination Tests and procedures may include photographs of the cornea iris and the structure through which fluid that normally circulates behind the cornea drains out of the eye Some patients may undergo indentation tonography to measure how easily this fluid drains In this procedure the patient lies on an examination table and both eyes are numbed with eye drops A small instrument tonometer is placed on the surface of one eye and with the other eye the patient looks at an overhead light Other tests may include photographs of the back of the eye and ultrasound imaging of the structures of the eye A blood sample may be drawn to study the genetic disorder responsible for the disease Patients will have follow-up examinations every 6 months for the duration of the study
Medical or surgical therapy will be recommended as appropriate for patients who develop elevated eye pressure or vision loss
Patients with eye anterior chamber eye disease such as Axenfelds syndrome Riegers anomaly Peters anomaly iridocorneal endothelial syndrome megalocornea ocular hypertension and others are eligible for this study Participants will have a medical examination family history and comprehensive eye examination Tests and procedures may include photographs of the cornea iris and the structure through which fluid that normally circulates behind the cornea drains out of the eye Some patients may undergo indentation tonography to measure how easily this fluid drains In this procedure the patient lies on an examination table and both eyes are numbed with eye drops A small instrument tonometer is placed on the surface of one eye and with the other eye the patient looks at an overhead light Other tests may include photographs of the back of the eye and ultrasound imaging of the structures of the eye A blood sample may be drawn to study the genetic disorder responsible for the disease Patients will have follow-up examinations every 6 months for the duration of the study
Medical or surgical therapy will be recommended as appropriate for patients who develop elevated eye pressure or vision loss
Detailed Description:
This study will concentrate on abnormalities of the anterior chamber with or without elevated intraocular pressure The purpose of the study will be to determine if there is a common pathogenesis shared by these conditions A natural history study of 40 individuals with these diseases will utilize clinical measurements and photographs for documentation of this hypothesis In addition surgical specimens when available will be studied
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 77-EI-0119 | None | None | None |