Ignite Creation Date:
2024-05-05 @ 4:59 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00368784
Status:
COMPLETED
Last Update Posted:
2021-03-05
First Post:
2006-08-24
Brief Title:
T Cell Repertoire Analysis of Immune Mediated Skin Diseases
Sponsor:
University of California Davis
Organization:
University of California Davis
Study Overview
Official Title:
T Cell Repertoire Analysis of Immune Mediated Skin Diseases
Status:
COMPLETED
Status Verified Date:
2021-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to identify the cells of the immune system that cause skin disease such as psoriasis and mycosis fungoides Blood samples from many patients will be compared in hopes of finding common cells and molecules responsible for skin diseases Results of this study will increase our knowledge about immune mediated skin disease
Detailed Description:
The aim of the study is to characterized the T cell repertoire of individuals with immune mediated skin disease eg psoriasis and mycosis fungoides Peripheral blood with be collected from volunteers with psoriasis mycosis fungoides and age matched controls Fifteen tablespoons of blood will be collected prior to the initiation of treatment and again after the patient shows a clinical response to treatment The time between blood draws will be no less than 3 months There will be no more than two blood draws per patient Blood samples will be used to determine the patients HLA haplotype via PCR and DNA sequencing After the patients haplotype has been established the activated T cell repertoire will be analyzed for clonal expansions Clonal expansions in the T cell repertoire will be determined by immunoscope analysis which is a PCR based technique
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None