Ignite Creation Date:
2024-05-05 @ 4:59 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00365495
Status:
UNKNOWN
Last Update Posted:
2007-04-04
First Post:
2006-08-15
Brief Title:
Influence of Physical Training on Mitochondrial Function in Type 2 Diabetic Patients
Sponsor:
Odense University Hospital
Organization:
Odense University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Physical activity as treatment for patients with type 2 diabetes T2D Treatment of T2D is often done by medication changing the diet and increased physical activity It is well established that physical training has a positive effect on the pathology of T2D such as increased insulin sensitivity and reduced fasting plasma glucose 7 and blood lipids 15 It is also well known that in healthy subjects endurance training increases mitochondrial density lipid oxidation during submaximal exercise and results in a number of qualitative changes in the control of OXPHOS 24 However the effect of physical training on the mitochondrial function in skeletal muscle of patients with T2D has not been investigated
The purpose of this project is to investigate the effect of physical training on the mitochondrial respiratory function in muscles of patients with T2D Skeletal muscle biopsies will be taken before and after 10 weeks of physical training in patients with T2D and matched control subjects Mitochondria will be isolated from the muscle biopsies and respiratory function free radical production and UCP3 will be determined Furthermore measures of maximal oxygen consumption VO2max heart rate and capillary lactate concentrations and carbohydrate and lipid oxidation will be determined partly to verify an increased aerobic capacity and partly to investigate the changes in these factors in T2D patients
The purpose of this project is to investigate the effect of physical training on the mitochondrial respiratory function in muscles of patients with T2D Skeletal muscle biopsies will be taken before and after 10 weeks of physical training in patients with T2D and matched control subjects Mitochondria will be isolated from the muscle biopsies and respiratory function free radical production and UCP3 will be determined Furthermore measures of maximal oxygen consumption VO2max heart rate and capillary lactate concentrations and carbohydrate and lipid oxidation will be determined partly to verify an increased aerobic capacity and partly to investigate the changes in these factors in T2D patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None