Ignite Creation Date:
2024-05-06 @ 1:41 PM
Last Modification Date:
2024-10-26 @ 1:18 PM
Study NCT ID:
NCT04093609
Status:
UNKNOWN
Last Update Posted:
2019-09-18
First Post:
2019-09-16
Brief Title:
XIST Gene Deletion in Breast Cancer Therapy
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Detection of XIST Gene Deletion by Fluorescence in Situ Hybridization in Patients With Breast Cancer and Its Relation With Different Response to Therapies
Status:
UNKNOWN
Status Verified Date:
2019-09
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Very little is known about the role of X-inactive specific transcript RNA in human breast cancer and in regulating different response to therapy
the relation between the breast cancer predisposing gene BRCA1 X-inactive specific transcript RNA has been investigated but still controversial
Loss of X chromosome inactivation XCI is observed in breast cancer Other studies sheds light on a possible mechanism of breast carcinogenesis mediated by XIST misbehaviour
the relation between the breast cancer predisposing gene BRCA1 X-inactive specific transcript RNA has been investigated but still controversial
Loss of X chromosome inactivation XCI is observed in breast cancer Other studies sheds light on a possible mechanism of breast carcinogenesis mediated by XIST misbehaviour
Detailed Description:
breast cancer is an important cause of morbidity and mortality in women Genetics of female contributes to her risk of having breast cancer this disease is still discovered in their late stages due to the negligence of females inspite of self inspection and clinical examination of the breast the identification of markers that could predict the tumor behavior is important in breast cancer management staging evaluation of therapeutic response and development of new therapeutic modalities XIST X-inactive specific transcript RNA is a long non -coding RNA which plays an important role in inactivation of x_ chromosome which act as an example for long non _ coding RNA mediated gene regulation Very little is known about the role of XIST in human breast cancer and in regulating different response on therapy the relation between the breast cancer predisposing gene BRCA1 XIST has been investigated but still controversial Loss of X chromosome inactivation XCI is observed in breast some studies provide evedience that BRCA1 Is involved in XIST regulation on the active X chromosome but not its localization other studies sheds light on a possible mechanism of breast carcinogenesis mediated by XIST misbehaviour
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None