Ignite Creation Date:
2024-05-06 @ 1:46 PM
Last Modification Date:
2024-10-26 @ 1:19 PM
Study NCT ID:
NCT04119492
Status:
UNKNOWN
Last Update Posted:
2020-10-12
First Post:
2018-12-19
Brief Title:
DCD ASD Imaging Intervention Study
Sponsor:
University of British Columbia
Organization:
University of British Columbia
Study Overview
Official Title:
Integrating Brain Imaging and Rehabilitation to Improve Outcomes for Children With Co-occurring DCD ASD
Status:
UNKNOWN
Status Verified Date:
2020-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Developmental Coordination Disorder DCD is a neurodevelopmental disorder that affects a childs ability to learn motor skills such as tying shoelaces learning to print or riding a bicycle APA 2013 It often co-occurs with other conditions such as Attention Deficit Hyperactivity Disorder ADHD Its high co-occurrence with Autism Spectrum Disorder ASD has only been permitted since 2013 so it is less well known Recent neuroimaging studies have begun to unravel the neural underpinnings of each disorder however few brain imaging studies have included children with co-occurring DCD and ASD The first aim of the proposed project is to understand brain structure and function in children with DCD-ASD Despite high co-occurrence of DCD and ASD Green 2009 motor impairment and functional problems are rarely the focus of therapy for children with ASD Current best-practice for improving motor function is an approach called Cognitive Orientation to Occupational Performance CO-OP The second aim of this study is to examine effectiveness of this treatment approach for children with DCDASD and determine if there are brain changes and improvements in motor skills as a result of intervention This novel project is the first to integrate brain imaging and motor-based rehabilitation in this population and builds on a current study examining brain changes in children with DCD with and without co-occurring ADHD Examining the neural basis of these motor difficulties in the presence or absence of co-occurring conditions will help to determine the neural correlates specific to DCD and whether the response to treatment differs in children with co-occurring conditions
Detailed Description:
About 5 of children have DCD a neurodevelopmental disorder that significantly affects their ability to learn motor skills such as tying shoelaces learning to print or riding a bicycle APA 2013 DCD interferes with school performance vocational activities leisure pursuits it has a lifelong impact and 75 of children with DCD will continue to experience motor difficulties as adults Kirby 2014 DCD is highly comorbid with other neurodevelopmental disorders including Autism Spectrum Disorder ASD Green 2009 and Attention Deficit Hyperactivity Disorder ADHD Piek 1999 which exacerbates childrens motor and functional problems Kirby 2014
Until recently motor deficits in children with ASD have largely been ignored Since the Diagnostic and Statistical Manual for Mental Disorders-5th ed DSM-5 was published in 2013 a dual diagnosis of ASD and DCD is now permitted Over 50 of children with ASD have been reported to have DCD Green 2009 with the degree of motor impairment correlating with autism severity Dzuik 2007
The overlap of DCD and ASD is not well-studied but the high co-occurrence prompts one to wonder whether there are common and distinct neural markers that define these neurodevelopmental disorders Neuroimaging studies have begun to unravel their neural underpinnings Abnormalities in the cerebellum DMello 2016 Foster 2015 Liu 2017 Zwicker 2009 2011 and corpus callosum Langevin 2014 Frazier 2009 are common to both disorders but few studies have compared children with DCD and those with co-occurring ASD Preliminary evidence indicates alterations in network patterns that are unique to the DCDASD group when compared to either single diagnosis of DCD or ASD Caeyenberghs 2016 As one of the first neuroimaging studies to touch upon a dual diagnosis of DCDASD Caeyenberghs et al found that paralimbic regions exhibit altered connectivity in singular disorders which are disorder specific to ASD or DCD however children meeting criteria for both DCD and ASD exhibit more widespread over-connectivity specifically in the left association area and medio-occipitotemporal gyrus when compared to DCD alone While in its infancy neuroimaging studies suggest that DCD and ASD may have common but also distinct neural underpinnings Caeyenberghs 2016 Caçola 2017 further research is needed to better understand the neural correlates of each disorder and its co-occurrence
Current best-practice to improve motor function in children with DCD is Cognitive Orientation to Occupational Performance CO-OP Smits-Engelsman 2013 CO-OP is a task-specific approach designed to improve motor-based skills that a child needs or wants to master it is a cognitive-based problem-solving approach that uses verbal mediation and identifies strategies to support skill acquisition Polatajko 2001 It is largely unknown if children with co-occurring DCD and ASD benefit from CO-OP Although motor impairment and functional problems are common in ASD they are rarely the focus of therapy The primary focus of therapy for children with ASD has always been on social and communication skills or managing sensory processing differences Preliminary findings from a case study with two children diagnosed with ASD suggest that CO-OP is feasible and able to induce clinically significant improvements in self- and parent-rated performance on each of their motor goals Rodger 2009 However a larger sample is needed to confirm these findings
The CO-OP approach has been effective in meeting child-chosen functional motor goals Polatajko 2001 Miller 2001 but the neural basis for these improvements is still not known The investigators are currently investigating brain changes in structure and function associated with CO-OP intervention for children with DCD-ADHD and would like to expand their study to include children with co-occurring ASD and DCD This novel study will help to unravel the brain differences between these co-occurring conditions and explain if and why rehabilitation may benefit children with the dual diagnosis of DCD and ASD
This study will provide clinicians and researchers with a greater understanding of neurological underpinnings of motor difficulties in children with ASD and whether interventions should include CO-OP therapy This project is the first to integrate brain imaging and motor-based intervention in this population and may provide evidence to support new clinical practices to improve outcomes
RESEARCH DESIGN
Specific Aims and Hypothesis The proposed study is designed to test the hypotheses that compared to children with DCD children with ASDDCD will exhibit overlapping but distinct differences in brain structure and function and that rehabilitation associated with brain differences will lead to improvements of motor function This study builds on the investigators current CIHR-funded study comparing typically-developing children with children with DCD-ADHD and neuroplasticity associated with CO-OP intervention The proposed study is designed to address the following specific aims
Aim 1 Characterize brain structure and function in children DCDASD and compare results to previously collected data on children with DCD-ADHD Hypotheses Compared to children with DCD brains of children with DCDASD will show smaller cerebellar volume differences in microstructural development in motor sensory cerebellar and frontal pathways and lower correlation between signals from brain regions corresponding to resting-state networks including default-mode sensorimotor cerebellar and frontal networks
Aim 2 Determine if CO-OP intervention induces neuroplastic changes in brain structure function and improves motor skills in children with DCDASD Hypotheses Compared to a waitlist control group children in the treatment group will show 1 strengthened functional connectivity in sensorimotor and cerebellar and frontal networks 2 increased integrity of the frontal-cerebellar pathway 3 increased gray matter volume in the dorsolateral prefrontal motor and cerebellar cortices and 4 improved motor performance A positive association between functional improvements and changes in brain structurefunction is also expected
Aim 3 Determine if neuroplastic and functional changes are retained at 3-month follow-up Hypothesis Children who maintained their functional gains will show increased functional connectivity in brain networks increased connectivity of the frontal-cerebellar pathway and increased gray matter volume as in Aim 2 compared to children who did not maintain their functional gains
Study Design and Sample Size Calculation This study is a randomized waitlisted controlled trial Children will be randomly assigned to either treatment or waitlist group A statistician will randomize participants using computer-generated sequential blocks of 4 to 6 randomization codes will be kept in sealed opaque envelopes until study enrollment Added to the investigators current study a sample of 30 participants with DCDASD will provide 80 power to detect clinically significant improvement of 2 points on the Canadian Occupational Performance Measure COPM Law 2014 26 SD of 25 and a type-1 error of 005 and a 3 difference in axial diffusivity on diffusion tensor imaging which was correlated with motor function in the investigators pilot work Zwicker 2012
Participants Thirty children 8-12 years who meet the diagnostic criteria for DCD and ASD as outlined in the DSM-5 APA 2013 will be eligible to participate
Brain Imaging Prior to MR imaging children will undergo an MRI simulator session to become familiar with the sights and sounds of the MR environment All imaging studies will be performed on a state-of-the-art 3-Tesla GE Discovery MR 750 scanner Brain structure will be assessed using 1 T1-weighted structural imaging to measure cerebral volume white matter cortical gray matter and deep gray matter and cerebellar volume and 2 diffusion tensor imaging DTI to measure structural connectivity and white matter microstructure throughout the brain Brain function will be measured indirectly using resting state MRI to examine functional connectivity at rest in various networks Total scan time is 30 min
Intervention CO-OP is a cognitive approach to solving functional motor problems Polatajko 2001 Therapists teach children a global problem-solving strategy Goal-Plan-Do-Check as means to develop specific strategies for overcoming motor problems the strategies are determined after a dynamic performance analysis by the therapist to determine where the breakdown is in performing the task Occupational therapists trained in CO-OP will see children for one hour once weekly for 10 weeks Parents or caregivers will be encouraged to attend treatment sessions so therapists can instruct them how to facilitate strategy use between treatment sessions Children will select 3 functional motor goals to be addressed during treatment rating their performance and satisfaction of these goals pre- and post-intervention
Measures The MABC-2 will be used to assess the degree of motor impairment scores 16th percentile indicate DCD Henderson 2007 This measure provides an overall total score compiled from eight subtests across 3 domains manual dexterity 3 aiming and catching 2 and balance 3 A commonly used parent questionnaire the DCDQ Wilson 2007 will be used to confirm impact of motor skills on daily function The Conners 3 AI-Parent form will be used to assess ADHD symptomology Conners 2001 The Social Communication Questionnaire SCQ a parent-report questionnaire will be used to screen for autism-specific social and communication impairments Rutter 2003
The primary outcome measure is the COPM Law 2014 which is an individualized client-centred measure designed to detect change in a clients self-perception of their performance and satisfaction over time on functional goals that are of importance to them To supplement the COPM investigators will video-tape the child performing their 3 motor goals before and after intervention An occupational therapist blinded to the intervention and pre-testpost-test will score the motor performance using the Performance Quality Rating Scale PQRS an objective and observational measure of performance quality Miller 2001 Fine and gross motor skills will be measured using the short form of the Bruninks-Oseretsky Test of Motor Proficiency 2nd ed BOT-2 Bruininks 2005
Neuroimaging Analysis DTI for analyzing diffusion tensor data tract-based spatial statistics TBSS using FMRIB Software Library FSL will be conducted TBSS is a fully automated approach that allows for whole-brain analysis without pre-specification of tracts of interest Smith 2006 T1-weighted imaging will be analyzed using voxel-based morphometry to compare the local concentration of grey matter between sessions and groups using Statistical Parametric Map-99 package Ashburner 2000 rs-MRI FSL will be used to conduct an independent component analysis which allows a data-driven approach to explore resting state networks Beckman 2005
Data Analysis
Aim 1 mean brain volumes will be compared between groups using ANOVAs with regression-based adjustment for age and sex Generalized Linear Model will compare DTI measures and functional connectivity timeseries in children with DCD DCDADHD DCDASD and controls
Aims 2 3 Repeated Measures ANCOVA will be applied to the primary and secondary outcomes to detect changes over time including effect of maturity in waitlist group intervention effect in both waitlist and treatment groups and late effect of intervention in treatment group Age MABC-2 scores and Conners scores will be used as covariates
Until recently motor deficits in children with ASD have largely been ignored Since the Diagnostic and Statistical Manual for Mental Disorders-5th ed DSM-5 was published in 2013 a dual diagnosis of ASD and DCD is now permitted Over 50 of children with ASD have been reported to have DCD Green 2009 with the degree of motor impairment correlating with autism severity Dzuik 2007
The overlap of DCD and ASD is not well-studied but the high co-occurrence prompts one to wonder whether there are common and distinct neural markers that define these neurodevelopmental disorders Neuroimaging studies have begun to unravel their neural underpinnings Abnormalities in the cerebellum DMello 2016 Foster 2015 Liu 2017 Zwicker 2009 2011 and corpus callosum Langevin 2014 Frazier 2009 are common to both disorders but few studies have compared children with DCD and those with co-occurring ASD Preliminary evidence indicates alterations in network patterns that are unique to the DCDASD group when compared to either single diagnosis of DCD or ASD Caeyenberghs 2016 As one of the first neuroimaging studies to touch upon a dual diagnosis of DCDASD Caeyenberghs et al found that paralimbic regions exhibit altered connectivity in singular disorders which are disorder specific to ASD or DCD however children meeting criteria for both DCD and ASD exhibit more widespread over-connectivity specifically in the left association area and medio-occipitotemporal gyrus when compared to DCD alone While in its infancy neuroimaging studies suggest that DCD and ASD may have common but also distinct neural underpinnings Caeyenberghs 2016 Caçola 2017 further research is needed to better understand the neural correlates of each disorder and its co-occurrence
Current best-practice to improve motor function in children with DCD is Cognitive Orientation to Occupational Performance CO-OP Smits-Engelsman 2013 CO-OP is a task-specific approach designed to improve motor-based skills that a child needs or wants to master it is a cognitive-based problem-solving approach that uses verbal mediation and identifies strategies to support skill acquisition Polatajko 2001 It is largely unknown if children with co-occurring DCD and ASD benefit from CO-OP Although motor impairment and functional problems are common in ASD they are rarely the focus of therapy The primary focus of therapy for children with ASD has always been on social and communication skills or managing sensory processing differences Preliminary findings from a case study with two children diagnosed with ASD suggest that CO-OP is feasible and able to induce clinically significant improvements in self- and parent-rated performance on each of their motor goals Rodger 2009 However a larger sample is needed to confirm these findings
The CO-OP approach has been effective in meeting child-chosen functional motor goals Polatajko 2001 Miller 2001 but the neural basis for these improvements is still not known The investigators are currently investigating brain changes in structure and function associated with CO-OP intervention for children with DCD-ADHD and would like to expand their study to include children with co-occurring ASD and DCD This novel study will help to unravel the brain differences between these co-occurring conditions and explain if and why rehabilitation may benefit children with the dual diagnosis of DCD and ASD
This study will provide clinicians and researchers with a greater understanding of neurological underpinnings of motor difficulties in children with ASD and whether interventions should include CO-OP therapy This project is the first to integrate brain imaging and motor-based intervention in this population and may provide evidence to support new clinical practices to improve outcomes
RESEARCH DESIGN
Specific Aims and Hypothesis The proposed study is designed to test the hypotheses that compared to children with DCD children with ASDDCD will exhibit overlapping but distinct differences in brain structure and function and that rehabilitation associated with brain differences will lead to improvements of motor function This study builds on the investigators current CIHR-funded study comparing typically-developing children with children with DCD-ADHD and neuroplasticity associated with CO-OP intervention The proposed study is designed to address the following specific aims
Aim 1 Characterize brain structure and function in children DCDASD and compare results to previously collected data on children with DCD-ADHD Hypotheses Compared to children with DCD brains of children with DCDASD will show smaller cerebellar volume differences in microstructural development in motor sensory cerebellar and frontal pathways and lower correlation between signals from brain regions corresponding to resting-state networks including default-mode sensorimotor cerebellar and frontal networks
Aim 2 Determine if CO-OP intervention induces neuroplastic changes in brain structure function and improves motor skills in children with DCDASD Hypotheses Compared to a waitlist control group children in the treatment group will show 1 strengthened functional connectivity in sensorimotor and cerebellar and frontal networks 2 increased integrity of the frontal-cerebellar pathway 3 increased gray matter volume in the dorsolateral prefrontal motor and cerebellar cortices and 4 improved motor performance A positive association between functional improvements and changes in brain structurefunction is also expected
Aim 3 Determine if neuroplastic and functional changes are retained at 3-month follow-up Hypothesis Children who maintained their functional gains will show increased functional connectivity in brain networks increased connectivity of the frontal-cerebellar pathway and increased gray matter volume as in Aim 2 compared to children who did not maintain their functional gains
Study Design and Sample Size Calculation This study is a randomized waitlisted controlled trial Children will be randomly assigned to either treatment or waitlist group A statistician will randomize participants using computer-generated sequential blocks of 4 to 6 randomization codes will be kept in sealed opaque envelopes until study enrollment Added to the investigators current study a sample of 30 participants with DCDASD will provide 80 power to detect clinically significant improvement of 2 points on the Canadian Occupational Performance Measure COPM Law 2014 26 SD of 25 and a type-1 error of 005 and a 3 difference in axial diffusivity on diffusion tensor imaging which was correlated with motor function in the investigators pilot work Zwicker 2012
Participants Thirty children 8-12 years who meet the diagnostic criteria for DCD and ASD as outlined in the DSM-5 APA 2013 will be eligible to participate
Brain Imaging Prior to MR imaging children will undergo an MRI simulator session to become familiar with the sights and sounds of the MR environment All imaging studies will be performed on a state-of-the-art 3-Tesla GE Discovery MR 750 scanner Brain structure will be assessed using 1 T1-weighted structural imaging to measure cerebral volume white matter cortical gray matter and deep gray matter and cerebellar volume and 2 diffusion tensor imaging DTI to measure structural connectivity and white matter microstructure throughout the brain Brain function will be measured indirectly using resting state MRI to examine functional connectivity at rest in various networks Total scan time is 30 min
Intervention CO-OP is a cognitive approach to solving functional motor problems Polatajko 2001 Therapists teach children a global problem-solving strategy Goal-Plan-Do-Check as means to develop specific strategies for overcoming motor problems the strategies are determined after a dynamic performance analysis by the therapist to determine where the breakdown is in performing the task Occupational therapists trained in CO-OP will see children for one hour once weekly for 10 weeks Parents or caregivers will be encouraged to attend treatment sessions so therapists can instruct them how to facilitate strategy use between treatment sessions Children will select 3 functional motor goals to be addressed during treatment rating their performance and satisfaction of these goals pre- and post-intervention
Measures The MABC-2 will be used to assess the degree of motor impairment scores 16th percentile indicate DCD Henderson 2007 This measure provides an overall total score compiled from eight subtests across 3 domains manual dexterity 3 aiming and catching 2 and balance 3 A commonly used parent questionnaire the DCDQ Wilson 2007 will be used to confirm impact of motor skills on daily function The Conners 3 AI-Parent form will be used to assess ADHD symptomology Conners 2001 The Social Communication Questionnaire SCQ a parent-report questionnaire will be used to screen for autism-specific social and communication impairments Rutter 2003
The primary outcome measure is the COPM Law 2014 which is an individualized client-centred measure designed to detect change in a clients self-perception of their performance and satisfaction over time on functional goals that are of importance to them To supplement the COPM investigators will video-tape the child performing their 3 motor goals before and after intervention An occupational therapist blinded to the intervention and pre-testpost-test will score the motor performance using the Performance Quality Rating Scale PQRS an objective and observational measure of performance quality Miller 2001 Fine and gross motor skills will be measured using the short form of the Bruninks-Oseretsky Test of Motor Proficiency 2nd ed BOT-2 Bruininks 2005
Neuroimaging Analysis DTI for analyzing diffusion tensor data tract-based spatial statistics TBSS using FMRIB Software Library FSL will be conducted TBSS is a fully automated approach that allows for whole-brain analysis without pre-specification of tracts of interest Smith 2006 T1-weighted imaging will be analyzed using voxel-based morphometry to compare the local concentration of grey matter between sessions and groups using Statistical Parametric Map-99 package Ashburner 2000 rs-MRI FSL will be used to conduct an independent component analysis which allows a data-driven approach to explore resting state networks Beckman 2005
Data Analysis
Aim 1 mean brain volumes will be compared between groups using ANOVAs with regression-based adjustment for age and sex Generalized Linear Model will compare DTI measures and functional connectivity timeseries in children with DCD DCDADHD DCDASD and controls
Aims 2 3 Repeated Measures ANCOVA will be applied to the primary and secondary outcomes to detect changes over time including effect of maturity in waitlist group intervention effect in both waitlist and treatment groups and late effect of intervention in treatment group Age MABC-2 scores and Conners scores will be used as covariates
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None