Ignite Creation Date:
2024-05-05 @ 5:00 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00367926
Status:
COMPLETED
Last Update Posted:
2006-08-23
First Post:
2006-08-22
Brief Title:
The Effect of American Ginseng Root and Its Components on Glycemia in Healthy Individuals
Sponsor:
Risk Factor Modification Centre
Organization:
Risk Factor Modification Centre
Study Overview
Official Title:
Effect of American Ginseng Root and Derived Polysaccharides on Postprandial Glycemia in Healthy Individuals
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the effect of polysaccharides from American ginseng root on postprandial glycemia in healthy individuals
Detailed Description:
Glycemia-lowering effects of American ginseng root have been repeatedly observed in healthy individuals and in type 2 diabetes It is unclear which components trigger these effects Pre-clinical evidence suggests that aside from ginseng saponins ginseng polysaccharides may reduce glycemia This assumption has not been investigated so far in humans
We therefore undertook a double-blind randomized controlled clinical trial to determine the effect of American ginseng root polysaccharides at escalating doses on postprandial glycemia in comparison to the American ginseng root and control in healthy individuals We hypothesized that polysaccharides will reduce glycemia comparably to a dose of ginseng root that contains polysaccharides at an equivalent amount to the average polysaccharide dose We therefore tested polysaccharide doses equivalent to 9 12 and 15 g of rot 12 go of ginseng root and a wheat bran control Each subject received each treatment in random sequence after a 12-hour overnight fast and 40 minutes prior to a 25-g oral glucose tolerance test Capillary blood samples were collected at baseline prior to glucose ingestion and at 15 30 45 60 90 120 minutes after the start of glucose intake Capillary blood glucose was measured
We therefore undertook a double-blind randomized controlled clinical trial to determine the effect of American ginseng root polysaccharides at escalating doses on postprandial glycemia in comparison to the American ginseng root and control in healthy individuals We hypothesized that polysaccharides will reduce glycemia comparably to a dose of ginseng root that contains polysaccharides at an equivalent amount to the average polysaccharide dose We therefore tested polysaccharide doses equivalent to 9 12 and 15 g of rot 12 go of ginseng root and a wheat bran control Each subject received each treatment in random sequence after a 12-hour overnight fast and 40 minutes prior to a 25-g oral glucose tolerance test Capillary blood samples were collected at baseline prior to glucose ingestion and at 15 30 45 60 90 120 minutes after the start of glucose intake Capillary blood glucose was measured
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MOP- 62943 | None | None | None |