Ignite Creation Date:
2024-05-06 @ 1:50 PM
Last Modification Date:
2024-10-26 @ 1:21 PM
Study NCT ID:
NCT04145453
Status:
COMPLETED
Last Update Posted:
2022-07-08
First Post:
2019-10-03
Brief Title:
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults
Sponsor:
Poznan University of Life Sciences
Organization:
Poznan University of Life Sciences
Study Overview
Official Title:
Can Including Genotype Information Increase the Effectiveness of Dietary Interventions Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults
Status:
COMPLETED
Status Verified Date:
2022-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Personalized nutrition is one of the most up to date trends in human nutrition and gains much interest of general public and scientists as well Although we have gained some knowledge on gene-trait associations the real effectiveness and usefulness of genotype-based nutritional recommendations is unknown Many personalized nutrition companies are on the market today some of them use personalized nutrition based on genotype analysis For this reason scientific basis of this approach should be clarified
Our project can thus increase knowledge which can be applied in dietary counseling practice Although we focus on increase vegetable and fruits intake the study is designed as a proof of concept
Our project can thus increase knowledge which can be applied in dietary counseling practice Although we focus on increase vegetable and fruits intake the study is designed as a proof of concept
Detailed Description:
In humans the TAS2R38 receptor gene is responsible for differences in the perception of bitter taste This gene codes for a G protein that is associated with a flavor receptor regulated by phenylthiocarbamide PTC and propylthiouracil PROP ligands which by binding to the receptor determines the degree of bitter taste Cruciferous vegetables contain glucosinolates and isothiocyanates which resemble PTC and PROP and thereby affect their perception of bitter taste through the TAS2R38 regulated receptor
The polymorphism of this gene allows to distinguish three phenotypes
insensitive to bitter taste bitter-non tasters
moderately sensitive to bitter taste intermediate-bitter tasters
sensitive to bitter taste bitter taster Previous studies have shown that people who are carriers of one PAV haplotype experience a bitter taste more than AVI AVI homozygotes which are less sensitive to bitter taste Hence the TAS2R38 gene polymorphism is associated with nutritional decisions including choice of vegetables and coffee
Aim of the study is to verify effectiveness of the genotype based dietary intervention in people with or without polymorphism of TAS2R38 gene
The polymorphism of this gene allows to distinguish three phenotypes
insensitive to bitter taste bitter-non tasters
moderately sensitive to bitter taste intermediate-bitter tasters
sensitive to bitter taste bitter taster Previous studies have shown that people who are carriers of one PAV haplotype experience a bitter taste more than AVI AVI homozygotes which are less sensitive to bitter taste Hence the TAS2R38 gene polymorphism is associated with nutritional decisions including choice of vegetables and coffee
Aim of the study is to verify effectiveness of the genotype based dietary intervention in people with or without polymorphism of TAS2R38 gene
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None