Ignite Creation Date:
2024-05-05 @ 5:01 PM
Last Modification Date:
2024-10-26 @ 9:26 AM
Study NCT ID:
NCT00361725
Status:
TERMINATED
Last Update Posted:
2006-08-15
First Post:
2006-08-07
Brief Title:
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients
Status:
TERMINATED
Status Verified Date:
2006-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a comparative study performed in 3 groups of patientssubjects 30 severe sepsis patients 30 non-septic patients with organ failure 30 healthy subjects
The only intervention is a venous blood sampling at the onset of the disease
The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event
The only intervention is a venous blood sampling at the onset of the disease
The purpose of the study is to compare the PC pathway and expression and inflammatory genes between the 3 groups The main hypothesis is that systemic inflammatory response and exacerbated coagulation activation are non specific of an infection as a triggering event
Detailed Description:
analysis of the PC pathway
PC activity
PS activity
soluble thrombomodulin
soluble EPCR
activated protein C
quantitative flow cytometry on monocytes thrombomodulin and EPCR
whole blood mRNA Tissue factor thrombomodulin and EPCR
inflammatory gene expression analysis by MLPA
PC activity
PS activity
soluble thrombomodulin
soluble EPCR
activated protein C
quantitative flow cytometry on monocytes thrombomodulin and EPCR
whole blood mRNA Tissue factor thrombomodulin and EPCR
inflammatory gene expression analysis by MLPA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None