Ignite Creation Date:
2024-05-05 @ 5:01 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00375375
Status:
COMPLETED
Last Update Posted:
2007-03-02
First Post:
2006-09-12
Brief Title:
Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life
Sponsor:
Post Graduate Institute of Medical Education and Research Chandigarh
Organization:
PIMERIndia
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2007-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Minimal hepatic encephalopathy MHE has a negative effect on patients daily functioning No study has so far investigated the effect of treatment related improvement in cognitive functions on health related quality-of-life HRQOL This study was carried out to determine the influence of treatment on psychomotor performance and on HRQOL in patients with MHE
The mean number of abnormal NP tests decreased significantly in patients in treated group compared with patients in untreated group MANOVA for time and treatment P 001 Mean total SIP score improved among patients in the treated group after 3 months compared with patients in untreated group after 3 months MANOVA for time and treatment P002 Improvement in HRQOL was related to the improvement in psychometry In conclusion treatment with lactulose improves both cognitive functions and HRQOL in cirrhotic patients with MHE
The mean number of abnormal NP tests decreased significantly in patients in treated group compared with patients in untreated group MANOVA for time and treatment P 001 Mean total SIP score improved among patients in the treated group after 3 months compared with patients in untreated group after 3 months MANOVA for time and treatment P002 Improvement in HRQOL was related to the improvement in psychometry In conclusion treatment with lactulose improves both cognitive functions and HRQOL in cirrhotic patients with MHE
Detailed Description:
The study has been published in March 2007 in Hepatology
Lactulose Improves Cognitive Functions and Health-Related Quality of Life in Patients with Cirrhosis WhoHave Minimal Hepatic EncephalopathySrinivasa Prasad Radha K Dhiman Ajay Duseja Yogesh K Chawla Arpita Sharma and Ritesh Agarwal HEPATOLOGY 200745549-559
Lactulose Improves Cognitive Functions and Health-Related Quality of Life in Patients with Cirrhosis WhoHave Minimal Hepatic EncephalopathySrinivasa Prasad Radha K Dhiman Ajay Duseja Yogesh K Chawla Arpita Sharma and Ritesh Agarwal HEPATOLOGY 200745549-559
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None