Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005544
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Community Based Study of Adult Onset Asthma
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify the role of irritant exposure in adult-onset asthma by simultaneously using both clinical and case control methods in a community-based perspective study of asthma incidence
Detailed Description:
BACKGROUND
Asthma incidence is increasing and in adults work-related exposures may be an important factor-occupational asthma OA incidence increased 70 percent over the last decade according to a recent registry based study The true contribution of occupational exposures to adult-onset asthma is unknown because the methods for measuring OA give conflicting results Methods based on surveillance of clinically diagnosed OA account for less than one to five percent of adult-onset asthma However case-control methods of measuring asthma risk by industry suggest that six to 33 percent of adult-onset asthma is caused by workplace exposures The conflict may occur because of two factors physicians often fail to diagnose and report OA and irritant exposures may increase the risk the risk of asthma without causing cases that meet the clinical definition Both factors have important implications for proper treatment and prevention of asthma in adults
DESIGN NARRATIVE
Clinical and case control methods were used to identify the role of irritant exposure in adult-onset asthma in a community-based prospective study of asthma incidence The study cohort was a typical US working population enrolled in an HMO Additional benefits of the study design were the opportunities to validate a questionnaire for exposure assessment and for detection of work-related asthma Specifically the study 1 Investigated incident cases in a cohort of over 80000 adults over three years and determined the proportion that met a clinical definition of occupational asthma OA 2 Used a nested case-control study to determine the incidence of all asthma by occupation and workplace exposure 3 Determined whether clinical OA accounted for the excess incidence of adult-onset asthma associated with workplace exposure to sensitizers and irritants 4 Prospectively followed asthmatics for two years after diagnosis to determine the impact of adult-onset asthma on lung function employment income and quality of life and to determine whether prognosis differed for clinical OA and for asthma associated with workplace irritant exposure 5 Tested an intervention designed to increase appropriate clinical diagnosis and thus secondary prevention of OA
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Asthma incidence is increasing and in adults work-related exposures may be an important factor-occupational asthma OA incidence increased 70 percent over the last decade according to a recent registry based study The true contribution of occupational exposures to adult-onset asthma is unknown because the methods for measuring OA give conflicting results Methods based on surveillance of clinically diagnosed OA account for less than one to five percent of adult-onset asthma However case-control methods of measuring asthma risk by industry suggest that six to 33 percent of adult-onset asthma is caused by workplace exposures The conflict may occur because of two factors physicians often fail to diagnose and report OA and irritant exposures may increase the risk the risk of asthma without causing cases that meet the clinical definition Both factors have important implications for proper treatment and prevention of asthma in adults
DESIGN NARRATIVE
Clinical and case control methods were used to identify the role of irritant exposure in adult-onset asthma in a community-based prospective study of asthma incidence The study cohort was a typical US working population enrolled in an HMO Additional benefits of the study design were the opportunities to validate a questionnaire for exposure assessment and for detection of work-related asthma Specifically the study 1 Investigated incident cases in a cohort of over 80000 adults over three years and determined the proportion that met a clinical definition of occupational asthma OA 2 Used a nested case-control study to determine the incidence of all asthma by occupation and workplace exposure 3 Determined whether clinical OA accounted for the excess incidence of adult-onset asthma associated with workplace exposure to sensitizers and irritants 4 Prospectively followed asthmatics for two years after diagnosis to determine the impact of adult-onset asthma on lung function employment income and quality of life and to determine whether prognosis differed for clinical OA and for asthma associated with workplace irritant exposure 5 Tested an intervention designed to increase appropriate clinical diagnosis and thus secondary prevention of OA
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL061302 | NIH | None | httpsreporternihgovquickSearchR01HL061302 |