Ignite Creation Date:
2024-05-06 @ 2:12 PM
Last Modification Date:
2024-10-26 @ 1:26 PM
Study NCT ID:
NCT04242082
Status:
UNKNOWN
Last Update Posted:
2020-05-08
First Post:
2020-01-21
Brief Title:
Glucose Trnsporter and PEDF in Psoriasis
Sponsor:
Assiut University
Organization:
Assiut University
Study Overview
Official Title:
Role of Glucose Transporter GLUT Genes Expression in Patients With Psoriasis
Status:
UNKNOWN
Status Verified Date:
2020-05
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Psoriasis is a chronic relapsing cutaneous immune mediated inflammatory diseaseIMID In which there are skin lesions characterized by erythema thickness and scale formation with different size from a pinhead to 20 cm in diameter Prevalence of psoriasis is 2 to 4 worldwide Psoriasis occurs at any age with two peaks between 15-20 years and between 55-60 years Women are presented with psoriasis at younger age than men but with less severity lesions usually present on knee elbow scalp and sacral region this may be attributed to higher traumatic incident
Psoriasis vulgaris is the most common type and accounts 90 of cases Patients with psoriasis vulgaris present with pain itching and bleeding from skin lesions
There are many theories for psoriasis pathogenesis angiogenesis decrease in apoptosis of keratinocyte hyperproliferation alteration of cell to cell adhesion and immune-mediated inflammation
Patients with immune mediated inflammatory disease IMID are susceptible to develop diabetes mellitus metabolic syndrome hyperlipidemia and hypertensionA previous study found that psoriatic patients are more susceptible to type 2 diabetes compared to control
Glucose transporter type 1GLUT1 is upregulated in psoriatic patient attributed to angiogenesis and execessive cell proliferation in those patients Also expression of GLUT 1 is found high with hyperglycemia A study reported that GLUT 1 density in placenta of women with gestational diabetes was found to be two folds higher than control
Pigment epithelium derived factor PEDF has antiangiogenic effect Topical application of PEDF on mouse model of psoriatic disease helps in reduction of skin proliferation and angiogenesis
GLUT 1 overexpression was found to be associated with decrease in PEDF expression in diabetic retinopathy
In view of that we will compare the level of GLUT 1 gene in psoriatic patients and psoriatic patients with diabetes as well as healthy control and detect the effect of PEDF on GLUT 1 expression in vitro using human keratinocytes cell line
Psoriasis vulgaris is the most common type and accounts 90 of cases Patients with psoriasis vulgaris present with pain itching and bleeding from skin lesions
There are many theories for psoriasis pathogenesis angiogenesis decrease in apoptosis of keratinocyte hyperproliferation alteration of cell to cell adhesion and immune-mediated inflammation
Patients with immune mediated inflammatory disease IMID are susceptible to develop diabetes mellitus metabolic syndrome hyperlipidemia and hypertensionA previous study found that psoriatic patients are more susceptible to type 2 diabetes compared to control
Glucose transporter type 1GLUT1 is upregulated in psoriatic patient attributed to angiogenesis and execessive cell proliferation in those patients Also expression of GLUT 1 is found high with hyperglycemia A study reported that GLUT 1 density in placenta of women with gestational diabetes was found to be two folds higher than control
Pigment epithelium derived factor PEDF has antiangiogenic effect Topical application of PEDF on mouse model of psoriatic disease helps in reduction of skin proliferation and angiogenesis
GLUT 1 overexpression was found to be associated with decrease in PEDF expression in diabetic retinopathy
In view of that we will compare the level of GLUT 1 gene in psoriatic patients and psoriatic patients with diabetes as well as healthy control and detect the effect of PEDF on GLUT 1 expression in vitro using human keratinocytes cell line
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None