Ignite Creation Date:
2024-05-05 @ 9:42 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001738
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Vascular Endothelial Growth Factor VEGF in Uveitis
Sponsor:
National Eye Institute NEI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Pilot Study to Demonstrate the Presence of Vascular Endothelial Growth Factor VEGF in Uveitic Cystoid Macular Edema
Status:
COMPLETED
Status Verified Date:
1999-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will look for the presence in blood of a substance called vascular endothelial growth factor VEGF in patients with uveitis eye inflammation It will also look for this substance in eye fluid samples taken from patients with uveitis who are undergoing eye surgery
Some patients with uveitis experience some vision loss during an inflammatory attack because of swelling edema in a particular area of the retina called the macula which is involved in visual acuity It may be that VEGF is involved in the development of macular edema
Patients with uveitis who participate in this study will have about 10 cc 2 teaspoons of blood drawn to be examined for VEGF They will also undergo a procedure called fluorescein angiography to look at the blood vessels of the eye A dye called sodium fluorescein is injected into the blood stream through a vein After the dye reaches the blood vessels of the eye photographs are taken of the retina
In addition patients with uveitis who are undergoing eye surgery will have a tissue specimen either aqueous fluid or vitreous gel collected for examination for the presence of VEGF
Some patients with uveitis experience some vision loss during an inflammatory attack because of swelling edema in a particular area of the retina called the macula which is involved in visual acuity It may be that VEGF is involved in the development of macular edema
Patients with uveitis who participate in this study will have about 10 cc 2 teaspoons of blood drawn to be examined for VEGF They will also undergo a procedure called fluorescein angiography to look at the blood vessels of the eye A dye called sodium fluorescein is injected into the blood stream through a vein After the dye reaches the blood vessels of the eye photographs are taken of the retina
In addition patients with uveitis who are undergoing eye surgery will have a tissue specimen either aqueous fluid or vitreous gel collected for examination for the presence of VEGF
Detailed Description:
Increased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor VEGF is associated with new vessel growth in the eye such as diabetic retinopathy Recent work using immunopathologic techniques have shown that VEGF is upregulated in both experimentally induced uveitis and in uveitic eyes as well with no evidence of neovascularization This pilot study will evaluate the level of VEGF in the blood of uveitic patients with and without macular edema This level will be determined also in the ocular fluid of those patients that are undergoing ocular surgery These levels will be compared with age and sex matched controls
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-EI-0152 | None | None | None |