Ignite Creation Date:
2024-05-05 @ 5:06 PM
Last Modification Date:
2024-10-26 @ 9:27 AM
Study NCT ID:
NCT00380757
Status:
COMPLETED
Last Update Posted:
2017-01-23
First Post:
2006-09-23
Brief Title:
Comparison of Bystander Fatigue and CPR Quality When Using Two Different CPR Ratios
Sponsor:
Ottawa Hospital Research Institute
Organization:
Ottawa Hospital Research Institute
Study Overview
Official Title:
Comparison of Bystander Fatigue and CPR Quality When Using the New 302 Versus the Old 152 Chest Compression to Ventilation International Guidelines A Randomised Crossover Trial
Status:
COMPLETED
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 302 versus the old 152 chest compression to ventilation International Resuscitation Guidelines in a population aged 55 or greater
More specifically we will compare each CPR ratio with regard to
1 The achieved frequency and depth of chest compressions
2 Participant rating of their perceived level of exertion and
3 Resulting serum lactate levels in a subset of the participants
STUDY HYPOTHESIS
In a population aged 55 or greater the new 302 CPR ratio will lead to
1 less frequent and shallower chest compressions over the 5-minute study period
2 higher rating of perceived level of exertion and
3 higher serum lactate levels in a subset of participants when compared to the old 152 CPR ratio
More specifically we will compare each CPR ratio with regard to
1 The achieved frequency and depth of chest compressions
2 Participant rating of their perceived level of exertion and
3 Resulting serum lactate levels in a subset of the participants
STUDY HYPOTHESIS
In a population aged 55 or greater the new 302 CPR ratio will lead to
1 less frequent and shallower chest compressions over the 5-minute study period
2 higher rating of perceived level of exertion and
3 higher serum lactate levels in a subset of participants when compared to the old 152 CPR ratio
Detailed Description:
Background Cardiac arrest is the number one cause of mortality in the Canadian population Out-of-hospital bystander cardiopulmonary resuscitation CPR is associated with a 3 to 4 fold increase in survival for cardiac arrest Any interruption in the delivery of chest compressions to cardiac arrest victims is detrimental on survival In an effort to minimize interruptions in chest compressions the new International Guidelines changed the long-recommended 152 compression to ventilation ratio to 302 Although the 302 ratio is meant to increase survival for cardiac arrest the ability of rescuers to deliver the new CPR ratio intervention has never been studied Little is known about the potential impact of the new recommendations on bystander fatigue and resulting CPR quality
Objectives The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 302 versus the old 152 chest compression to ventilation International Guidelines in a population aged 55 or greater
More specifically we will compare each CPR ratio with regard to
1 The achieved frequency and depth of chest compressions
2 Participant rating of their perceived level of exertion and
3 Resulting serum lactate levels in a subset of the participants
Methods We will conduct a randomized cross-over trial comparing bystander fatigue and CPR quality using two different CPR ratios Intervention All participants will be asked to perform two 5-minute sessions of CPR on a recording manikin - one session using the 302 ratio the other using the 152 ratio There will be a supervised practice session in the beginning and resting periods in between The order in which the sessions will be executed will be determined in a random fashion The study population will consist of volunteers aged 55 or older a group most susceptible to perform CPR on a real victim The study will take place in a busy public area of The Ottawa Hospital Civic Campus between the cafeteria and the emergency department Participants will have to score 3 or less on the validated Clinical Frailty Scale in order to participate in the study Participants with physical limitations or disease processes precluding their ability to safely perform CPR will be excluded Outcome measures Information on age gender height weight prior CPR training and measure of frailty will be collected at the time of enrollment The number frequency and quality of chest compressions depth and release will be measured during each CPR session using a recording ResusciAnne manikin Heart rate and blood pressure will be measured before and after each CPR sessions The participants will be asked to rate their level of fatigue before and after each CPR session using the validated Borg Rating of Perceived Exertion scale In addition serum lactate levels will be determined before and after each CPR session in volunteers from the second group Sample size We hope to recruit 42 participants among which 10 will have their lactate levels measured Data analysis for Objective1 and 3 will include descriptive statistics and a paired t-test with 95 confidence interval Objective2 will be analyzed using descriptive statistics and WIlcoxon Rank Sum test In addition we will perform a stepwise logistic regression analysis to control for the potential confounding effects of variables otherwise associated with bystander fatigue and CPR performance using both CPR ratio This study protocol will receive ascent form the OHREB before implementation and will be entered on the OHRI randomized trial registry
Importance of the study Data from this study will evaluate bystander fatigue and resulting CPR quality when comparing the new 302 to the old 152 International Guidelines This highly innovative project will improve our understanding of the physiological demands associated with the implementation of the new CPR International Guidelines We anticipated the results from this study will be widely distributed and will help shape the next iteration of the International Resuscitation Guidelines
Objectives The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of the new 302 versus the old 152 chest compression to ventilation International Guidelines in a population aged 55 or greater
More specifically we will compare each CPR ratio with regard to
1 The achieved frequency and depth of chest compressions
2 Participant rating of their perceived level of exertion and
3 Resulting serum lactate levels in a subset of the participants
Methods We will conduct a randomized cross-over trial comparing bystander fatigue and CPR quality using two different CPR ratios Intervention All participants will be asked to perform two 5-minute sessions of CPR on a recording manikin - one session using the 302 ratio the other using the 152 ratio There will be a supervised practice session in the beginning and resting periods in between The order in which the sessions will be executed will be determined in a random fashion The study population will consist of volunteers aged 55 or older a group most susceptible to perform CPR on a real victim The study will take place in a busy public area of The Ottawa Hospital Civic Campus between the cafeteria and the emergency department Participants will have to score 3 or less on the validated Clinical Frailty Scale in order to participate in the study Participants with physical limitations or disease processes precluding their ability to safely perform CPR will be excluded Outcome measures Information on age gender height weight prior CPR training and measure of frailty will be collected at the time of enrollment The number frequency and quality of chest compressions depth and release will be measured during each CPR session using a recording ResusciAnne manikin Heart rate and blood pressure will be measured before and after each CPR sessions The participants will be asked to rate their level of fatigue before and after each CPR session using the validated Borg Rating of Perceived Exertion scale In addition serum lactate levels will be determined before and after each CPR session in volunteers from the second group Sample size We hope to recruit 42 participants among which 10 will have their lactate levels measured Data analysis for Objective1 and 3 will include descriptive statistics and a paired t-test with 95 confidence interval Objective2 will be analyzed using descriptive statistics and WIlcoxon Rank Sum test In addition we will perform a stepwise logistic regression analysis to control for the potential confounding effects of variables otherwise associated with bystander fatigue and CPR performance using both CPR ratio This study protocol will receive ascent form the OHREB before implementation and will be entered on the OHRI randomized trial registry
Importance of the study Data from this study will evaluate bystander fatigue and resulting CPR quality when comparing the new 302 to the old 152 International Guidelines This highly innovative project will improve our understanding of the physiological demands associated with the implementation of the new CPR International Guidelines We anticipated the results from this study will be widely distributed and will help shape the next iteration of the International Resuscitation Guidelines
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None