Ignite Creation Date:
2024-05-06 @ 2:27 PM
Last Modification Date:
2024-10-26 @ 1:31 PM
Study NCT ID:
NCT04326738
Status:
COMPLETED
Last Update Posted:
2022-02-10
First Post:
2020-03-26
Brief Title:
The Effect of Midazolam on Dexamethasone-induced Perineal Pruritus
Sponsor:
Yangzhou University
Organization:
Yangzhou University
Study Overview
Official Title:
The Effect of Midazolam on Dexamethasone-induced Perineal Pruritus
Status:
COMPLETED
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dexamethasone is commonly used in clinical practiceHowever intravenous dexamethasone sodium phosphate may cause perineal discomfortWith the popularization of comfortable medical technology patients have higher and higher requirements for comfortable medical treatmentPerineal pruritus caused by intravenous dexamethasone sodium phosphate may cause adverse physiological and psychological effects on patients and increase the incidence of unpleasant experiences during anesthesiaTherefore it is very important to find a practical and effective method of inhibitionMidazolam is a water-soluble benzodiazepine commonly used in clinical practice which has been proved to effectively inhibit the itching caused while its effect on the itching caused by dexamethasone has not been reportedBy observing the effect of pre-injection midazolam on the perineal itching caused by dexamethasone sodium phosphate this experiment intends to preliminarily explore its possible mechanism
Detailed Description:
Nighty patients scheduled for selective surgeryaged 18-65yearsASA physical status IIIBMI 1830kgm-2 were selected in this studyThe patients were equally randomized into two groups midazolam M group and normal saline N group 45 cases in each group Before anesthesia induction M group received intravenous injection of 003mgkg-1 1mgml-1 midazolam while N group received corresponding intravenous normal saline of the same volume After 1 min both groups received intravenous injection of dexamethasone sodium phosphate injection of 10mg injection was completed in 2s The anesthesiologist assessed perineal irritation in both groups and recorded the number of casesvisual analogue scores VAS duration of itching or painRamsay scores and observed the occurrence of adverse reactions such as dizziness and respiratory depression in the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None