Ignite Creation Date:
2024-05-06 @ 2:27 PM
Last Modification Date:
2024-10-26 @ 1:31 PM
Study NCT ID:
NCT04320303
Status:
UNKNOWN
Last Update Posted:
2021-06-11
First Post:
2020-03-23
Brief Title:
CMV Infection and Immune Intervention After Transplantation
Sponsor:
Peking University Peoples Hospital
Organization:
Peking University Peoples Hospital
Study Overview
Official Title:
CMV Infection and Immune Intervention After Haploidentical Hematopoietic Stem Cell Transplantation
Status:
UNKNOWN
Status Verified Date:
2021-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Allogeneic hematopoietic stem cell transplantation allo-HSCT is an effective or even the only way to cure blood malignant diseases Cytomegalovirus CMV infection is a serious early complication of allo-HSCT Its high incidence and poor prognosis can cause a series of terminal organ diseases such as CMV pneumonia encephalitis and enteritiswhich seriously affecting the prognosis of patients post allo-HSCT
Our data show that rapid reconstruction of NK cells after transplantation can reduce the incidence of CMV infection Patients with a rapid reconstruction of NKG2C after transplantation have a low CMV infection rate and patients with strong secretion of IFN-gamma of NK after transplantation have low CMV infection
Our previous research showed that trophoblast cells transfected with IL-21 and 4-1BBL can achieve a large number of clinical-grade expansion of NK cells mIL-21 4-1BBL NK cells and mIL-21 4-1BBL NK cells It is safe to treat patients with minimal residual disease MRD positive AML after transplantation and can induce MRD to turn negative Previous studies have shown that adoptive infusion of expanded NK cells after haplotype transplantation is safe and can improve the functional reconstruction of NK cells Therefore we hypothesized that the infusion of NK cells can improve the antiviral capacity of NK cells thereby effectively reducing the CMV infection Incidence
Our data show that rapid reconstruction of NK cells after transplantation can reduce the incidence of CMV infection Patients with a rapid reconstruction of NKG2C after transplantation have a low CMV infection rate and patients with strong secretion of IFN-gamma of NK after transplantation have low CMV infection
Our previous research showed that trophoblast cells transfected with IL-21 and 4-1BBL can achieve a large number of clinical-grade expansion of NK cells mIL-21 4-1BBL NK cells and mIL-21 4-1BBL NK cells It is safe to treat patients with minimal residual disease MRD positive AML after transplantation and can induce MRD to turn negative Previous studies have shown that adoptive infusion of expanded NK cells after haplotype transplantation is safe and can improve the functional reconstruction of NK cells Therefore we hypothesized that the infusion of NK cells can improve the antiviral capacity of NK cells thereby effectively reducing the CMV infection Incidence
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None