Ignite Creation Date:
2024-05-06 @ 2:30 PM
Last Modification Date:
2024-10-26 @ 1:32 PM
Study NCT ID:
NCT04334044
Status:
COMPLETED
Last Update Posted:
2021-07-07
First Post:
2020-04-01
Brief Title:
Treatment of SARS Caused by COVID-19 With Ruxolitinib
Sponsor:
Grupo Cooperativo de Hemopatías Malignas
Organization:
Grupo Cooperativo de Hemopatías Malignas
Study Overview
Official Title:
Treatment of Severe Acute Respiratory Syndrome Caused by COVID-19 With Ruxolitinib
Status:
COMPLETED
Status Verified Date:
2021-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In December 2019 a new virus emerged in Wuhan China rapidly becoming a pandemic with registered cases above 800000 around the world The virus is now known as SARS-CoV2 calling its disease coronavirus-19 or COVID-19 The mortality of the virus has been reported around 2-10 and its causes because of the proinflammatory immune response generated on the host The cytokines involved in the immune response to COVID-19 are IL-1 IL-2 IL4 IL-6 IL-10 IL-12 IL-13 IL-17 GCSF MCSF IP-10 MCP-1 MIP-1α HGF IFN-γ y TNF-α
Ruxolitinib is an inhibitor of JAK 12 which is responsable for multiple cellular signals including the proinflammatory IL-6 Ruxolitinib works as and immunomodulator decreasing the cytotoxic T lymphocytes and increasing the Treg cells
This study is intended to stop the disregulated immune response caused by COVID-19 that generates the pneumonia and subsequent severe acute respiratory syndrome
Ruxolitinib is an inhibitor of JAK 12 which is responsable for multiple cellular signals including the proinflammatory IL-6 Ruxolitinib works as and immunomodulator decreasing the cytotoxic T lymphocytes and increasing the Treg cells
This study is intended to stop the disregulated immune response caused by COVID-19 that generates the pneumonia and subsequent severe acute respiratory syndrome
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None