Ignite Creation Date:
2024-05-06 @ 2:30 PM
Last Modification Date:
2024-10-26 @ 1:32 PM
Study NCT ID:
NCT04337073
Status:
COMPLETED
Last Update Posted:
2022-02-25
First Post:
2020-04-03
Brief Title:
The Effect of Propofol on Dexamethasone-induced Perineal Pruritus
Sponsor:
Yangzhou University
Organization:
Yangzhou University
Study Overview
Official Title:
The Effect of Propofol on Dexamethasone-induced Perineal Pruritus
Status:
COMPLETED
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
patients may appear serious perineal itching after injection of dexamethasone sodium phosphate injection its incidence is about 25 100 and the incidence of the discomfort in females was much higher than that of the maleTo investigate the effect of propofol pretreatment on perineal pruritus induced by dexamethasone sodium phosphate injection and explore the possible machanisms
Detailed Description:
40 patients scheduled for selective surgeryaged 18-65yearsASA physical status IIIBMI 1830kgm2 were selected in this studyThe patients were equally randomized into two groups propofol P group and normal saline N group 20 cases in each group Before anesthesia induction M group received intravenous injection of 03mgkg propofol while N group received corresponding intravenous normal saline of the same volume After 1 min both groups received intravenous injection of dexamethasone sodium phosphate injection of 10mg The anesthesiologist assessed perineal irritation in both groups and recorded Ramsay scoresthe number of cases visual analogue scaleVAS scores duration of itching and observed the occurrence of adverse reactions such as dizziness hypotension and respiratory depression in the two groups
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None