Ignite Creation Date:
2024-05-06 @ 2:38 PM
Last Modification Date:
2024-10-26 @ 1:34 PM
Study NCT ID:
NCT04376476
Status:
COMPLETED
Last Update Posted:
2023-04-05
First Post:
2020-04-28
Brief Title:
Host-pathogen Interactions During SARS-CoV-2 Infection
Sponsor:
Hospices Civils de Lyon
Organization:
Hospices Civils de Lyon
Study Overview
Official Title:
Host-pathogen Interactions During Paediatric and Adult SARS-CoV-2 Infection COVID-19
Status:
COMPLETED
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HPI-COVID-19
Brief Summary:
The new Severe acute respiratory syndrome coronavirus SARS-CoV-2 named coronavirus disease 2019 COVID-19 is currently responsible for a pandemic spread of febrile respiratory infections responsible for a veritable global health crisis
In adults several evolutionary patterns are observed i apauci-symptomatic forms ii severe forms immediately linked to rare extensive viral pneumonia and iii forms of moderate severity some of which progress to secondary aggravation Day 7-Day 10 Children can be affected but are more rarely symptomatic and severe pediatric forms are exceptional
Like some other coronaviruses SARS-CoV and Middle East respiratory syndrome coronavirus MERS-CoV these differences in clinical expression could be based on a variability in the immunological response notably either via inhibition of the type I interferon IFN-I response or on the contrary an immunological dysregulation responsible for a cytokine storm associated with the aggravation Little is known about the impact of these innate immune response abnormalities on the adaptive response In addition certain genetic factors predisposing to a state of hyper-fragility and certain viral virulence factors could also be predictive of the clinical response
In this context the main hypothesis is that the virological analysis and the initial biological and immunological profiles are correlated with the initial clinical presentation of COVID-19 infection In particular children forms and pauci-symptomatic disease in adults may be linked to a more robust innate immune response including better production of IFN-I
In adults several evolutionary patterns are observed i apauci-symptomatic forms ii severe forms immediately linked to rare extensive viral pneumonia and iii forms of moderate severity some of which progress to secondary aggravation Day 7-Day 10 Children can be affected but are more rarely symptomatic and severe pediatric forms are exceptional
Like some other coronaviruses SARS-CoV and Middle East respiratory syndrome coronavirus MERS-CoV these differences in clinical expression could be based on a variability in the immunological response notably either via inhibition of the type I interferon IFN-I response or on the contrary an immunological dysregulation responsible for a cytokine storm associated with the aggravation Little is known about the impact of these innate immune response abnormalities on the adaptive response In addition certain genetic factors predisposing to a state of hyper-fragility and certain viral virulence factors could also be predictive of the clinical response
In this context the main hypothesis is that the virological analysis and the initial biological and immunological profiles are correlated with the initial clinical presentation of COVID-19 infection In particular children forms and pauci-symptomatic disease in adults may be linked to a more robust innate immune response including better production of IFN-I
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2020-A01102-37 | OTHER | ID-RCB | None |