Ignite Creation Date:
2024-05-05 @ 5:07 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00395356
Status:
COMPLETED
Last Update Posted:
2006-11-02
First Post:
2006-11-01
Brief Title:
Efficacy and Feasibility of an Intermittent Weight Loss Program
Sponsor:
Université de Sherbrooke
Organization:
Université de Sherbrooke
Study Overview
Official Title:
Efficacy and Feasibility of an Intermittent Weight Loss Program A Pilot Study
Status:
COMPLETED
Status Verified Date:
2006-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of the study is to measure the effect of an approach including phases of active weight loss broken by weight stabilisation periods named intermittent weight loss on the metabolic profile
First the intermittent weight loss approach will contribute to create an artificial transitory steady state during the weight loss treatment that will help to minimize the adverse effects of the standard approach on muscle mass and resting metabolic rate Second despite a comparable fat mass loss the intermittent weight loss approach will improve the metabolic profile to a greater degree compared to the standard approach Finally the intermittent weight loss approach will be associated with less weight regain after the treatment since the beneficial effect on muscle mass and metabolic rate
First the intermittent weight loss approach will contribute to create an artificial transitory steady state during the weight loss treatment that will help to minimize the adverse effects of the standard approach on muscle mass and resting metabolic rate Second despite a comparable fat mass loss the intermittent weight loss approach will improve the metabolic profile to a greater degree compared to the standard approach Finally the intermittent weight loss approach will be associated with less weight regain after the treatment since the beneficial effect on muscle mass and metabolic rate
Detailed Description:
Excessive levels of body fat are associated with metabolic disturbances predictive of an increased risk of coronary heart disease CAD It is presently unclear as to the magnitude of weight loss needed to accrue metabolic benefits Despite the effectiveness of weight loss to reduce obesity levels studies have shown that only minor decreases in body weight 5-10 are needed to clinically improve CAD risk factors Our data suggested that a 10 reduction in body weight is as effective in improving the metabolic profile as a 20 decrease in body weight Thus the question are Is it possible to further improve the metabolic profile over that 5-10 weight loss threshold and Could several 5-10 body weight loss intermittent weight loss approach have additive effects on the metabolic profile We would like to follow-up on these observation to better understand 1 the association between weight loss and improvements in the metabolic profile and 2 why minor decreases in body composition and body fat distribution are as effective as more important reduction
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None