Ignite Creation Date:
2024-05-05 @ 5:08 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00397592
Status:
COMPLETED
Last Update Posted:
2007-07-03
First Post:
2006-11-08
Brief Title:
Growth Hormones Effect on Endothelial Progenitor Cells
Sponsor:
Vanderbilt University
Organization:
Vanderbilt University
Study Overview
Official Title:
The Effect of Exogenous Growth Hormone on the Mobilization of Endothelial Progenitor Cells
Status:
COMPLETED
Status Verified Date:
2007-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To assess the effect of short-term low-dose growth hormone therapy on the mobilization of endothelial progenitor cells from the bone marrow within a group of healthy adults
Detailed Description:
We are proposing a pilot study to assess the effect of the administration of recombinant human growth hormone on the number of endothelial progenitor cells EPCs in the peripheral circulation An increase in the number of EPCs is viewed as beneficial as it has been postulated that they provide an endogenous repair mechanism to counteract endothelial injury Additionally a reduced number of EPCs has been found to independently predict atherosclerotic disease progression Mechanisms proposed for enhancing the number of circulating EPCs and their function include an increase in proliferation mobilization from the bone marrow or prevention of EPC apoptosis Thus a pharmacologic manipulation of the number of EPCs in the peripheral circulation could potentially serve as a mechanism by which endothelial function and thus vascular health may be improved
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1515 | None | None | None |