Ignite Creation Date:
2024-05-05 @ 5:08 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00390624
Status:
COMPLETED
Last Update Posted:
2008-06-03
First Post:
2006-10-19
Brief Title:
Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
Sponsor:
Rocky Mountain Cancer Centers
Organization:
Rocky Mountain Cancer Centers
Study Overview
Official Title:
Prevention Of Nephrotoxicity Following Allogeneic Bone Marrow Transplantation Using Urodilatin UlaritideAtrial Natriuretic Peptide and Mannitol
Status:
COMPLETED
Status Verified Date:
2008-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
No
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to combine Urodilatin ANP analogue which will increase glomerular filtration rate GFR and mannitol which will increase the rate of urinary flow and solute excretion We intend to treat twenty consecutive allogeneic bone marrow transplant patients in a phase II study comparing results with historical controls
We hypothesize that the incidence of renal dysfunction ARF and thus mortality in allogeneic bone marrow transplantation can be significantly reduced by the use of protective agents Urodilatin and mannitol We feel that this combination is best administered prior to and during the first two weeks of treatment when patients encounter immunosuppressive agents and the onset of early transplantation complications
We hypothesize that the incidence of renal dysfunction ARF and thus mortality in allogeneic bone marrow transplantation can be significantly reduced by the use of protective agents Urodilatin and mannitol We feel that this combination is best administered prior to and during the first two weeks of treatment when patients encounter immunosuppressive agents and the onset of early transplantation complications
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None