Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005102
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
2000-04-06
Brief Title:
Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
OBJECTIVES
I Determine the pattern of immunologic reconstitution in patients with T-cell compromise due to DiGeorge syndrome or velocardiofacial syndrome
II Determine any correlation between immunologic function in these patients and chromosome 22 deletion breakpoints
III Determine presence of sustained immunologic compromise in older patients
I Determine the pattern of immunologic reconstitution in patients with T-cell compromise due to DiGeorge syndrome or velocardiofacial syndrome
II Determine any correlation between immunologic function in these patients and chromosome 22 deletion breakpoints
III Determine presence of sustained immunologic compromise in older patients
Detailed Description:
PROTOCOL OUTLINE
Blood samples are collected at diagnosis of chromosome 22q11 deletion and assessed for lymphocyte proliferation in response to mitogens phytohemagglutinin pokeweed mitogen and concanavalin A mitogen stimulation analyses These analyses are repeated at 4 months along with a quantitative analysis of immunoglobulin
At 8 months patients are tested for their lymphocytes ability to respond to antigens candida tetanus and diphtheria At 1 year patients have lymphocyte subset IgG IgA and IgM analyses performed Quantitative evaluations of antibody titers to diphtheria tetanus Haemophilus influenza and hepatitis B are also performed
Over 1 year of age all studies are performed if the patient is seen for a single visit
Blood samples are collected at diagnosis of chromosome 22q11 deletion and assessed for lymphocyte proliferation in response to mitogens phytohemagglutinin pokeweed mitogen and concanavalin A mitogen stimulation analyses These analyses are repeated at 4 months along with a quantitative analysis of immunoglobulin
At 8 months patients are tested for their lymphocytes ability to respond to antigens candida tetanus and diphtheria At 1 year patients have lymphocyte subset IgG IgA and IgM analyses performed Quantitative evaluations of antibody titers to diphtheria tetanus Haemophilus influenza and hepatitis B are also performed
Over 1 year of age all studies are performed if the patient is seen for a single visit
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CHP-GCRC-1571 | None | None | None |
| CHP-IRB-95-903 | None | None | None |