Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00395928
Status:
COMPLETED
Last Update Posted:
2006-11-06
First Post:
2006-11-02
Brief Title:
Chronic and Acute Effects of Smoking on the Left and Right Ventricular Relaxation in Young Healthy Smokers
Sponsor:
Medical University of Warsaw
Organization:
Medical University of Warsaw
Study Overview
Official Title:
Chronic and Acute Effect of Smoking on the Left and Right Ventricular Systolic and Diastolic Function in Young Healthy Smokers
Status:
COMPLETED
Status Verified Date:
2006-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Impairment of relaxation the early phase of ventricular diastole is the first stage of heart diastolic dysfunction Left ventricular diastolic function can be determined noninvasively by Echo- Doppler - derived mitral valve flow velocities The addition of pulmonary venous flow pattern enables more accurate assessment of left ventricle diastolic function The role of the right ventricle in haemodynamic function of the heart is now emphasized The right ventricle diastolic function can be assess by recording the Doppler tricuspid valve flow pattern Impaired LV diastolic function usually precedes systolic dysfunction and may cause clinical signs of congestive heart failure Cigarette smoking is one of the major risk factors for cardiovascular diseases The aim of the study was to assess left and right ventricular diastolic function in healthy young and slim smokers before and after smoking one cigarette
Echocardiographic examination before and after smoking one cigarette Echocardiographic evaluation of mitral valve flow pulmonary venous flow tricuspid valve flow and hepatic vein flow to assess diastolic function of ventricles
Echocardiographic examination before and after smoking one cigarette Echocardiographic evaluation of mitral valve flow pulmonary venous flow tricuspid valve flow and hepatic vein flow to assess diastolic function of ventricles
Detailed Description:
Echocardiographic examination in left lateral position after 10 minutes rest The first examination after a 2-hour non-smoking period the second immediately after smoking one cigarette containing 09 mg of nicotine The duration of the second examination no more than 15 minutes
Echocardiography equipment Hewlett-Packard SONOS 2000 Andover Massachusetts imaging system The transducers frequency 2 MHz
From the apical four chamber view the visualisation of transmitral flow pulmonary venous flow and transtricuspid flow From subcostal view the visualisation of right superior hepatic vein and the hepatic vein flow
Echocardiography equipment Hewlett-Packard SONOS 2000 Andover Massachusetts imaging system The transducers frequency 2 MHz
From the apical four chamber view the visualisation of transmitral flow pulmonary venous flow and transtricuspid flow From subcostal view the visualisation of right superior hepatic vein and the hepatic vein flow
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None