Ignite Creation Date:
2024-05-05 @ 5:09 PM
Last Modification Date:
2024-10-26 @ 9:28 AM
Study NCT ID:
NCT00393432
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2006-10-26
Brief Title:
Enhancing Motor Task Training by Action Observation Watching Others Perform the Task
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Enhancing Motor Memory Encoding by Action Observation
Status:
COMPLETED
Status Verified Date:
2008-07-18
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine how the brain learns a new motor task when the subject practices the task and watches others perform it action observation at the same time
Healthy normal volunteers between 18 and 55 years of age may be eligible for this study Candidates are screened with a medical history general and neurological exam and a brain MRI if one has not been done within 12 months of entering the study Participants undergo one or both of the following experiments
1 Effect of Transcranial Magnetic Stimulation on Motor Training and Action Observation
Subjects participate in at least 12 4-hour test sessions separated by at least 1 day Each session includes the following
Functional MRI fMRI MRI scanning uses a magnetic field and radio waves to produce images of the brain For fMRI the subject performs tasks during the scan to allow researchers to see brain changes that occur during performance of the activity
Transcranial magnetic stimulation TMS For this test a wire coil is held on the scalp A brief electrical current passes through the coil to stimulate the brain The stimulation may cause a twitch in muscles of the face arm or leg and the subject may hear a click and feel a pulling sensation on the skin under the coil During the stimulation the subject is asked to 1 perform the training task make brisk thumb movements 2 watch a video showing the hand of another person performing the same task and 3 perform the task and watch the video at the same time synchronizing his or her movements with those observed in the video
Surface electromyography Electrodes are filled with a conductive gel and taped to the skin over a hand muscle to measure the electrical activity of the muscle
Behavioral measurements Evaluation of learned movement tasks
Questionnaires to test attention fatigue and mood before during and after each test session
2 Effect of Pharmacological Agents on Motor Training and Action Observation
Subjects participate in no more than 12 5-hour test sessions separated by at least 2 days In the course of the 12 sessions subjects receive each of three medications - dextromethorphan scopolamine and rivastigmine - three times and a placebo pill with no active ingredient three times During each session subjects have TMS measurements behavioral measurements and electromyography as described in experiment 1
Healthy normal volunteers between 18 and 55 years of age may be eligible for this study Candidates are screened with a medical history general and neurological exam and a brain MRI if one has not been done within 12 months of entering the study Participants undergo one or both of the following experiments
1 Effect of Transcranial Magnetic Stimulation on Motor Training and Action Observation
Subjects participate in at least 12 4-hour test sessions separated by at least 1 day Each session includes the following
Functional MRI fMRI MRI scanning uses a magnetic field and radio waves to produce images of the brain For fMRI the subject performs tasks during the scan to allow researchers to see brain changes that occur during performance of the activity
Transcranial magnetic stimulation TMS For this test a wire coil is held on the scalp A brief electrical current passes through the coil to stimulate the brain The stimulation may cause a twitch in muscles of the face arm or leg and the subject may hear a click and feel a pulling sensation on the skin under the coil During the stimulation the subject is asked to 1 perform the training task make brisk thumb movements 2 watch a video showing the hand of another person performing the same task and 3 perform the task and watch the video at the same time synchronizing his or her movements with those observed in the video
Surface electromyography Electrodes are filled with a conductive gel and taped to the skin over a hand muscle to measure the electrical activity of the muscle
Behavioral measurements Evaluation of learned movement tasks
Questionnaires to test attention fatigue and mood before during and after each test session
2 Effect of Pharmacological Agents on Motor Training and Action Observation
Subjects participate in no more than 12 5-hour test sessions separated by at least 2 days In the course of the 12 sessions subjects receive each of three medications - dextromethorphan scopolamine and rivastigmine - three times and a placebo pill with no active ingredient three times During each session subjects have TMS measurements behavioral measurements and electromyography as described in experiment 1
Detailed Description:
Motor training MT elicits formation of motor memories in the human primary motor cortex Observing another individual perform motor training Action Observation AO also results in formation of motor memories in M1 AO enhances motor training effects MTAO on the formation of motor memories Possible underlying mechanisms include long-term potentiation LTP a process influenced by N-methyl-D-aspartate NMDA receptor activation gamma-aminobutyric acid GABA norepinephrine NE dopamine and acetylcholine Ach taking place at the confluence of inputs from PMv over the primary motor cortex M1
The purpose of this protocol is to gain insight into the mechanisms underlying motor memory formation by MTAO We plan to perform two different types of experiments In experiment 1 we will modulate activity in PMv using TMS to investigate the role of this cortical area on motor memory formation induced by MTAO In experiment 2 we will test the effects of single doses of a the NMDA receptor antagonist dextromethorphan b the muscarinic receptor antagonist scopolamine both known to disrupt LTP and c the cholinesterase inhibitor rivastigmine which enhances LTP
The primary outcome measure of motor memory formation will be the percentage of TMS-evoked movements that fall within the training target zone TTZ before and after MTAO The secondary outcome measure will be the percentage of TMS-evoked movements that fall within TTZ before and after MT alone and AO alone
Expected results are 1 upregulation of activity in PMv using 01 Hz TMS will enhance motor memory formation induced by MTAO more than sham TMS and downregulation of PMv using 09 Hz TMS and 2 dextromethorphan and scopolamine will decrease but rivastigmine will increase motor memory formation induced by MTAO with placebo This study may provide useful information on the mechanisms underlying the beneficial effects of action observation on neuroplasticity
The purpose of this protocol is to gain insight into the mechanisms underlying motor memory formation by MTAO We plan to perform two different types of experiments In experiment 1 we will modulate activity in PMv using TMS to investigate the role of this cortical area on motor memory formation induced by MTAO In experiment 2 we will test the effects of single doses of a the NMDA receptor antagonist dextromethorphan b the muscarinic receptor antagonist scopolamine both known to disrupt LTP and c the cholinesterase inhibitor rivastigmine which enhances LTP
The primary outcome measure of motor memory formation will be the percentage of TMS-evoked movements that fall within the training target zone TTZ before and after MTAO The secondary outcome measure will be the percentage of TMS-evoked movements that fall within TTZ before and after MT alone and AO alone
Expected results are 1 upregulation of activity in PMv using 01 Hz TMS will enhance motor memory formation induced by MTAO more than sham TMS and downregulation of PMv using 09 Hz TMS and 2 dextromethorphan and scopolamine will decrease but rivastigmine will increase motor memory formation induced by MTAO with placebo This study may provide useful information on the mechanisms underlying the beneficial effects of action observation on neuroplasticity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 07-N-0010 | None | None | None |