Ignite Creation Date:
2024-05-06 @ 2:57 PM
Last Modification Date:
2024-10-26 @ 1:40 PM
Study NCT ID:
NCT04471961
Status:
RECRUITING
Last Update Posted:
2024-04-03
First Post:
2020-07-10
Brief Title:
Analyse of Tumour and Constitutional DNA for the Study of the Determinism in Child Neoplasia
Sponsor:
University Hospital Montpellier
Organization:
University Hospital Montpellier
Study Overview
Official Title:
Analyse of Tumour and Constitutional DNA for the Study of the Determinism in Child Neoplasia
Status:
RECRUITING
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ALADIN
Brief Summary:
Background Cancer is the leading cause of death by disease in children Most pediatric tumors differ from adult tumors in terms of biological and clinical characteristics In children the part of genetic determinism could be higher since the role of environmental factors may be less pronounced than in adults and that a young age at onset is a main feature of genetic cancer predisposition Recent studies suggested that a number of genetic predisposition remains to be characterized
Methods Trio-Based whole exome sequencing of germline DNA from patients children and adults diagnosed with cancers between 0 and 17 years and parents will be performed prospectively in a multicentric study including 40 unselected cases of malignant tumor Participating hospitals will include the CHU of Montpellier the CHU de Nice and the AP-HP Tumor analysis will include whole exome analysis and transcriptome for the identification of therapeutic target and contribute to confirm potential link between constitutive mutations and tumor phenotype such as loss of expression loss of heterozygosity
Perspectives This pediatric oncology study proposing a global approach integrating trio-based whole exome sequencing somatic DNA and RNA analysis will improve the recognition of genetic predisposition and the characterization of target therapies in children with cancer
Methods Trio-Based whole exome sequencing of germline DNA from patients children and adults diagnosed with cancers between 0 and 17 years and parents will be performed prospectively in a multicentric study including 40 unselected cases of malignant tumor Participating hospitals will include the CHU of Montpellier the CHU de Nice and the AP-HP Tumor analysis will include whole exome analysis and transcriptome for the identification of therapeutic target and contribute to confirm potential link between constitutive mutations and tumor phenotype such as loss of expression loss of heterozygosity
Perspectives This pediatric oncology study proposing a global approach integrating trio-based whole exome sequencing somatic DNA and RNA analysis will improve the recognition of genetic predisposition and the characterization of target therapies in children with cancer
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2020-A0298-31 | OTHER | IDRCB | None |