Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005483
Status:
COMPLETED
Last Update Posted:
2016-01-08
First Post:
2000-05-25
Brief Title:
Plasma Homocysteine Distribution in the United States
Sponsor:
Tufts University
Organization:
Tufts University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To describe the distribution of homocysteine and prevalence of hyperhomocysteinemia with emphasis on race sex and age To determine the extent to which hyperhomocysteinemia is associated with status of folate and vitamin B12 Finally to describe the relationships between prevalence of hyperhomocysteinemia and prevalence of cardiovascular disease and assess the importance of this risk factor as a cause of vascular disease among US adults The study was renewed for one year to investigate normal homocysteine concentrations among children and to identify nutritional and non-nutritional determinants of total homocysteine concentrations in children
Detailed Description:
BACKGROUND
Hyperhomocysteinemia a condition of elevated plasma homocysteine concentrations resulting from impaired sulfur amino acid metabolism may be a powerful risk factor for occlusive vascular disease However little is known about the distribution of hyperhomocysteinemia in the general population Furthermore inadequate nutritional status might be a strong determinant of hyperhomocysteinemia but its importance at a population level as measured by the prevalence of hyperhomocysteinemia associated with inadequate nutrition has received little study Finally levels of homocysteine associated with elevated risk of vascular disease have not been clearly established
DESIGN NARRATIVE
Using previously collected plasma samples studies were conducted on the distribution of homocysteine and prevalence of hyperhomocysteinemia with emphasis on race sex and age Investigations were undertaken on the extent of the relationship of hyperhomocysteinemia to folate and vitamin B12 Finally the relationships were described between prevalence of hyperhomocysteinemia and prevalence of cardiovascular disease and the importance of this risk factor as a cause of vascular disease among US adults was assessed
Hyperhomocysteinemia a condition of elevated plasma homocysteine concentrations resulting from impaired sulfur amino acid metabolism may be a powerful risk factor for occlusive vascular disease However little is known about the distribution of hyperhomocysteinemia in the general population Furthermore inadequate nutritional status might be a strong determinant of hyperhomocysteinemia but its importance at a population level as measured by the prevalence of hyperhomocysteinemia associated with inadequate nutrition has received little study Finally levels of homocysteine associated with elevated risk of vascular disease have not been clearly established
DESIGN NARRATIVE
Using previously collected plasma samples studies were conducted on the distribution of homocysteine and prevalence of hyperhomocysteinemia with emphasis on race sex and age Investigations were undertaken on the extent of the relationship of hyperhomocysteinemia to folate and vitamin B12 Finally the relationships were described between prevalence of hyperhomocysteinemia and prevalence of cardiovascular disease and the importance of this risk factor as a cause of vascular disease among US adults was assessed
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL052630 | NIH | None | httpsreporternihgovquickSearchR01HL052630 |