Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005207
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Renin and Prorenin in Pregnancy
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the role of the prorenin-renin-angiotensin-aldosterone system RAAS in normal and hypertensive pregnancy
Detailed Description:
BACKGROUND
The renin-angiotensin system is involved in the physiology of pregnancy in two ways Circulating angiotensin II affects blood pressure renal hemodynamics and uteroplacental blood flow Abnormalities in angiotensin II production rates in hypertensive pregnancy contribute to the hemodynamic changes seen in the disease Additionally there is a form of the renin-angiotensin system in kidney ovary and placenta whose function is regulated by prorenin Prorenin activated by a specific receptor is involved in the regulation of steroid hormone biosynthesis and renal and uteroplacental blood flow
The study was conducted in response to a Request for Applications on Research on Hypertension in Pregnancy jointly released in 1986 by the National Heart Lung and Blood Institute and the National Institute of Child Health and Human Development
DESIGN NARRATIVE
The study was longitudinal in design Measurements were made of glomerular filtration rate renal plasma flow or uterine blood flow To define first trimester changes studies were conducted on in vitro fertilization and ovarian failure patients who had a broad spectrum of plasma prorenins Since interrelated changes in renin and prostaglandins may participate in the pathogenesis of hypertensive pregnancy RAAS prostaglandins and uteroplacental flow velocity profiles were monitored during a placebo-controlled trial of low-dose aspirin in chronic hypertensives
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The renin-angiotensin system is involved in the physiology of pregnancy in two ways Circulating angiotensin II affects blood pressure renal hemodynamics and uteroplacental blood flow Abnormalities in angiotensin II production rates in hypertensive pregnancy contribute to the hemodynamic changes seen in the disease Additionally there is a form of the renin-angiotensin system in kidney ovary and placenta whose function is regulated by prorenin Prorenin activated by a specific receptor is involved in the regulation of steroid hormone biosynthesis and renal and uteroplacental blood flow
The study was conducted in response to a Request for Applications on Research on Hypertension in Pregnancy jointly released in 1986 by the National Heart Lung and Blood Institute and the National Institute of Child Health and Human Development
DESIGN NARRATIVE
The study was longitudinal in design Measurements were made of glomerular filtration rate renal plasma flow or uterine blood flow To define first trimester changes studies were conducted on in vitro fertilization and ovarian failure patients who had a broad spectrum of plasma prorenins Since interrelated changes in renin and prostaglandins may participate in the pathogenesis of hypertensive pregnancy RAAS prostaglandins and uteroplacental flow velocity profiles were monitored during a placebo-controlled trial of low-dose aspirin in chronic hypertensives
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL040152 | NIH | None | httpsreporternihgovquickSearchR01HL040152 |