Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005657
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2000-05-06
Brief Title:
Genetics of Hepatitis C Virus Infection
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Immunogenetics of Hepatitis C Virus Infection
Status:
COMPLETED
Status Verified Date:
2011-04-19
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The diverse clinical syndromes associated with hepatitis C underscore the multifactorial and polygenic nature of HCV infection Both viral and host factors likely contribute to variations in infection outcome disease susceptibility and progression and treatment response This protocol will focus on the immunogenetics of HCV infection Various candidate genes most of them related to host immune response in microbial infection have defined genetic polymorphisms that have been associated with variable manifestations of infections including malaria tuberculosis leprosy AIDS and hepatitis B In this proposal we plan to collect peripheral blood mononuclear cells as a source of DNA from approximately 1500 patients with HCV infection analyze genetic polymorphisms of various candidate genes in association with viral clearance disease progression or treatment response and characterize the functional consequences of these polymorphisms in patients with well-defined clinical sequelae of HCV infection We will also collect blood from patients with other forms of liver diseases approximately 300 or normal volunteers approximately 200 as controls By identifying relevant host factors genetically and investigating their molecular interactions with HCV we may gain additional insights into HCV pathogenesis and uncover new potential targets for vaccine development and treatment intervention
Detailed Description:
The diverse clinical syndromes associated with hepatitis C underscore the multifactorial and polygenic nature of HCV infection Both viral and host factors likely contribute to variations in infection outcome disease susceptibility and progression and treatment response This protocol will focus on the immunogenetics of HCV infection Various candidate genes most of them related to host immune response in microbial infection have defined genetic polymorphisms that have been associated with variable manifestations of infections including malaria tuberculosis leprosy AIDS and hepatitis B In this proposal we plan to collect peripheral blood mononuclear cells as a source of DNA from approximately 1500 patients with HCV infection analyze genetic polymorphisms of various candidate genes in association with viral clearance disease progression or treatment response and characterize the functional consequences of these polymorphisms in patients with well-defined clinical sequelae of HCV infection We will also collect blood from patients with other forms of liver diseases approximately 300 or normal volunteers approximately 200 as controls By identifying relevant host factors genetically and investigating their molecular interactions with HCV we may gain additional insights into HCV pathogenesis and uncover new potential targets for vaccine development and treatment intervention
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-DK-0125 | None | None | None |