Ignite Creation Date:
2024-05-05 @ 5:13 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00412672
Status:
WITHDRAWN
Last Update Posted:
2015-06-16
First Post:
2006-12-15
Brief Title:
Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction
Sponsor:
Insel Gruppe AG University Hospital Bern
Organization:
Insel Gruppe AG University Hospital Bern
Study Overview
Official Title:
Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction
Status:
WITHDRAWN
Status Verified Date:
2015-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction
Detailed Description:
The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction
The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index CPI as obtained by transthoracic MCE
Extent of LV remodelling ie LV dilatation as assessed by serial assessment of LV dimension by LV angiogram andor echocardiography respectively
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction
The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index CPI as obtained by transthoracic MCE
Extent of LV remodelling ie LV dilatation as assessed by serial assessment of LV dimension by LV angiogram andor echocardiography respectively
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None