Ignite Creation Date:
2024-05-05 @ 5:13 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00417534
Status:
UNKNOWN
Last Update Posted:
2007-07-03
First Post:
2006-12-29
Brief Title:
Genetic Predisposition of Coronary Artery Disease -- The COROGENE-Study
Sponsor:
University of Helsinki
Organization:
University of Helsinki
Study Overview
Official Title:
Genetic Predisposition of Coronary Artery Disease in Patients Verified With Coronary Angiogram The COROGENE-Study
Status:
UNKNOWN
Status Verified Date:
2006-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to identify genetic locior gene variations contributing to inflammation and to the development of CHD We will compare coronary angiogram results to genetic findings within coronary artery disease patients and in patients with normal coronaries
Detailed Description:
Coronary artery disease CAD is a chronic inflammatory disease progression of which may be accelerated by immunological mechanisms Genes involved in regulation of inflammation and protection against infectious agents may affect picture of the disease Major Histocompatibility Complex MHC region carries genes involved in innate and adaptive immunity and inflammation We have for the first time identified genetic factors located in HLA region showing several fold risk for disease predisposition likely forming an important component to explain the high incidence of coronary heart disease in the Finnish population
The aim of this study is to rerun our preliminary results and further identify genetic loci or gene variations contributing to the development of CHD The strategy is to collect altogether 5000 patients assigned to coronary angiogram in Helsinki University Central Hospital We will compare the angiogram results to genetic findings first in patients with normal coronaries and in patients with different stages of CHD Secondly we will compare phenotypic changes in inflammation and try to find out if the phenotype differs in different genotypes Thirdly we will collect patients from hospital discharge registry and compare mortality and morbidity results in different gene groups
Finally we aim to record echocardiograms of the aortic valves in altogether 3500 consecutive patients undergoing coronary angiography We try to identify genetic loci and gene variations contributing to the fibrosis and calcification of the aortic valve
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage and needing for preventive medicine
The aim of this study is to rerun our preliminary results and further identify genetic loci or gene variations contributing to the development of CHD The strategy is to collect altogether 5000 patients assigned to coronary angiogram in Helsinki University Central Hospital We will compare the angiogram results to genetic findings first in patients with normal coronaries and in patients with different stages of CHD Secondly we will compare phenotypic changes in inflammation and try to find out if the phenotype differs in different genotypes Thirdly we will collect patients from hospital discharge registry and compare mortality and morbidity results in different gene groups
Finally we aim to record echocardiograms of the aortic valves in altogether 3500 consecutive patients undergoing coronary angiography We try to identify genetic loci and gene variations contributing to the fibrosis and calcification of the aortic valve
The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage and needing for preventive medicine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None